Yaman Mehmet, Kilinc Ali Y, Öztürk Fatih, Coşkun Mehmet, Duz Ramazan, Gunes Yılmaz
Cardiology Department, Echomar Hospital, Zonguldak, Turkey.
Department of Cardiology, Haseki Training and Research Hospital, Istanbul, Turkey.
Postepy Kardiol Interwencyjnej. 2024 Dec;20(4):401-405. doi: 10.5114/aic.2024.145034. Epub 2024 Nov 14.
Coronary artery disease (CAD) is common worldwide and is a significant cause of morbidity and mortality. CAD is a chronic and inflammatory disease mainly caused by atherosclerosis. SYNTAX and Gensini scoring systems are used to evaluate CAD extent and severity. Uric acid to high-density lipoprotein (HDL) ratio (UHR) increases in inflammatory conditions.
To investigate the relationship between UHR and the extent and severity of CAD and its correlation with SYNTAX and Gensini scoring systems.
894 patients who underwent angiography were included in the study. 612 participants with critical coronary stenosis were designated as the patient group, and 282 participants without stenosis were designated as the control group. Characteristic features and laboratory parameters of the groups were compared. The relationship between the SYNTAX and Gensini scores of the patient group and UHR was analyzed.
Baseline characteristics and laboratory parameters were similar in both groups, except for uric acid and UHR levels. Both uric acid levels (7.58 ±2.55 mg/dl vs. 5.71 ±1.46 mg/dl, < 0.01) and UHR (0.2016 ±0.094 vs. 0.1461 ±0.05, < 0.01) were significantly higher in the patient group. UHR levels were found to be correlated significantly with both scoring systems. In the ROC curve analysis the UHR cut-off value of 0.1567 was able to predict CAD moderately (AUC = 0.669 (0.634-0.704), sensitivity 61.1%, specificity 38.7%).
UHR is an easy-to-use parameter that can be used before invasive evaluation to predict the presence, severity, and extent of CAD.
冠状动脉疾病（CAD）在全球范围内普遍存在，是发病和死亡的重要原因。CAD是一种主要由动脉粥样硬化引起的慢性炎症性疾病。SYNTAX和Gensini评分系统用于评估CAD的范围和严重程度。在炎症状态下，尿酸与高密度脂蛋白（HDL）的比值（UHR）会升高。
研究UHR与CAD的范围和严重程度之间的关系，及其与SYNTAX和Gensini评分系统的相关性。
本研究纳入了894例行血管造影的患者。612例患有严重冠状动脉狭窄的参与者被指定为患者组，282例无狭窄的参与者被指定为对照组。比较两组的特征和实验室参数。分析患者组的SYNTAX和Gensini评分与UHR之间的关系。
除尿酸和UHR水平外，两组的基线特征和实验室参数相似。患者组的尿酸水平（7.58±2.55mg/dl对5.71±1.46mg/dl，<0.01）和UHR（0.2016±0.094对0.1461±0.05，<0.01）均显著更高。发现UHR水平与两个评分系统均显著相关。在ROC曲线分析中，UHR临界值0.1567能够中度预测CAD（AUC = 0.669（0.634 - 0.704），敏感性61.1%，特异性38.7%）。
UHR是一个易于使用的参数，可在侵入性评估前用于预测CAD的存在、严重程度和范围。
