Key Laboratory of Industrial Biotechnology of Ministry of Education & School of Biotechnology, Jiangnan University, Wuxi, Jiangsu, China.
Biomedical Sciences College & Shandong Medicinal Biotechnology Centre, Shandong First Medical University & Shandong Academy of Medical Sciences, Ji'nan, China.
Crit Rev Biotechnol. 2022 Dec;42(8):1260-1283. doi: 10.1080/07388551.2021.1987856. Epub 2021 Oct 27.
is the largest and most significant genus of Actinobacteria, comprising 961 species. These Gram-positive bacteria produce many versatile and important bioactive compounds; of these, antibiotics, specifically the enhancement or activation of their production, have received extensive research attention. Recently, various biotic and abiotic elicitors have been reported to modify the antibiotic metabolism of , which promotes the production of new antibiotics and bioactive metabolites for improvement in the yields of endogenous products. However, some elicitors that obviously contribute to secondary metabolite production have not yet received sufficient attention. In this study, we have reviewed the functions and mechanisms of chemicals, novel microbial metabolic elicitors, microbial interactions, enzymes, enzyme inhibitors, environmental factors, and novel combination methods regarding antibiotic production in This review has aimed to identify potentially valuable elicitors for stimulating the production of latent antibiotics or enhancing the synthesis of subsistent antibiotics in . Future applications and challenges in the discovery of new antibiotics and enhancement of existing antibiotic production using elicitors are discussed.
是放线菌门中最大和最重要的属，包含 961 个种。这些革兰氏阳性细菌产生许多多功能和重要的生物活性化合物；其中，抗生素，特别是增强或激活其生产，受到了广泛的研究关注。最近，已经报道了各种生物和非生物诱导剂可以改变 的抗生素代谢，从而促进新抗生素和生物活性代谢物的产生，以提高内源性产物的产量。然而，一些明显有助于次生代谢产物生产的诱导剂尚未得到足够的重视。在本研究中，我们回顾了化学物质、新型微生物代谢诱导剂、微生物相互作用、酶、酶抑制剂、环境因素和新型组合方法在 抗生素生产中的功能和机制。本综述旨在确定有潜在价值的诱导剂，以刺激潜在抗生素的产生或增强现有抗生素的合成。讨论了未来应用和利用诱导剂发现新抗生素和增强现有抗生素生产的挑战。
