全胃切除术后 26 年复发胃癌致肺肿瘤性血栓性微血管病。
Pulmonary Tumor Thrombotic Microangiopathy Caused by Recurrent Gastric Cancer 26 Years After Total Gastrectomy.
机构信息
Department of Internal Medicine, Division of Cardiovascular Medicine, Aijinkai Takatsuki General Hospital, Japan.
Department of Pathology, Aijinkai Takatsuki General Hospital, Japan.
出版信息
Intern Med. 2022 Jul 1;61(13):1969-1972. doi: 10.2169/internalmedicine.8559-21. Epub 2021 Oct 26.
Pulmonary tumor thrombotic microangiopathy (PTTM) is a rare cancer-related complication that induces pulmonary hypertension (PH). PTTM can be caused by recurrent cancer, with 12 years being the longest reported interval from primary cancer to the development of PTTM. We herein report a 74-year-old woman who presented with dyspnea due to PH. The postmortem diagnosis was PTTM caused by recurrent gastric cancer 26 years after total gastrectomy. An autopsy revealed PTTM-specific histological characteristics. Our findings indicate that PTTM should be considered as a diagnosis for patients with a history of cancer who develop PH, even several decades after treatment.
肺肿瘤性血栓微血管病（PTTM）是一种罕见的癌症相关并发症，可导致肺动脉高压（PH）。PTTM 可由复发性癌症引起，从原发性癌症到 PTTM 发展的最长报告间隔为 12 年。本文报告了一例 74 岁女性因 PH 出现呼吸困难。尸检诊断为全胃切除术后 26 年复发胃癌引起的 PTTM。尸检显示 PTTM 具有特定的组织学特征。我们的研究结果表明，对于患有癌症并发生 PH 的患者，即使在治疗后几十年，也应考虑 PTTM 作为诊断。
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