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一种负责在非洲爪蟾发育的囊胚中期转变时激活转录的增强子。

An enhancer responsible for activating transcription at the midblastula transition in Xenopus development.

作者信息

Krieg P A, Melton D A

出版信息

Proc Natl Acad Sci U S A. 1987 Apr;84(8):2331-5. doi: 10.1073/pnas.84.8.2331.

DOI:10.1073/pnas.84.8.2331
PMID:3470796
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC304644/
Abstract

Transcripts from the Xenopus gene GS17 are absent from oocytes and first appear at the midblastula transition (MBT), about 8 hr after fertilization. Injection experiments with deletions of the GS17 gene and GS17-beta-globin hybrid genes show that a relatively short sequence of 74 base pairs is sufficient to activate, in cis, transcription at the MBT. This 74-base sequence is located about 700 bases upstream of the GS17 promoter and has the properties of an enhancer element.

摘要

非洲爪蟾基因GS17的转录本在卵母细胞中不存在，最早在囊胚中期转换（MBT）时出现，即在受精后约8小时。对GS17基因缺失和GS17-β-珠蛋白杂交基因的注射实验表明，一段相对较短的74个碱基对的序列足以顺式激活MBT时的转录。这个74碱基序列位于GS17启动子上游约700个碱基处，具有增强子元件的特性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d49/304644/4e91a2bfcf19/pnas00273-0232-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d49/304644/5deee26957e9/pnas00273-0230-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d49/304644/fc011050ac7c/pnas00273-0231-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d49/304644/604ea752fb05/pnas00273-0231-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d49/304644/fc908d7e6909/pnas00273-0231-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d49/304644/4e91a2bfcf19/pnas00273-0232-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d49/304644/5deee26957e9/pnas00273-0230-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d49/304644/fc011050ac7c/pnas00273-0231-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d49/304644/604ea752fb05/pnas00273-0231-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d49/304644/fc908d7e6909/pnas00273-0231-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d49/304644/4e91a2bfcf19/pnas00273-0232-a.jpg

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引用本文的文献

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本文引用的文献

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将携带细菌氯霉素乙酰转移酶基因且带有非洲爪蟾心脏α-肌动蛋白启动子的线性化质粒DNA注射到非洲爪蟾受精卵后，其表达在时间上不受控制。
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Identification of a potential regulator of early transcriptional responses to mesoderm inducers in the frog embryo.青蛙胚胎中中胚层诱导因子早期转录反应潜在调节因子的鉴定。
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