Süleyman Demirel University, Faculty of Medicine, Department of Cardiology - Isparta, Turkey.
Rev Assoc Med Bras (1992). 2021 Jun;67(6):868-872. doi: 10.1590/1806-9282.20210198.
The predictive value of the fibrinogen-to-albumin ratio has been evidenced in coronary artery disease. Available data demonstrated that inflammation and oxidative stress are the relevant mechanisms of ascending aortic aneurysm formation and dilatation. The fibrinogen-to-albumin ratio reflects oxidative stress and inflammation. This study investigated the correlation between fibrinogen-to-albumin ratio and ascending aortic aneurysm.
A total of 250 consecutive patients with ascending aortic aneurysm and 250 consecutive patients with normal ascending aortic diameter were included in the study using comprehensive transthoracic echocardiography. All data and fibrinogen-to-albumin ratio were compared between two groups.
The fibrinogen-to-albumin ratio levels were significantly higher in ascending aortic aneurysm group compared with normal ascending aortic diameter group (p<0.001). Also, there was significantly positive correlation between the diameter of the ascending aorta and the fibrinogen-to-albumin ratio (p<0.001).
Fibrinogen-to-albumin ratio is associated with ascending aortic aneurysm and may serve as blood marker for identifying high-risk patients.
纤维蛋白原与白蛋白比值的预测价值已在冠状动脉疾病中得到证实。现有数据表明，炎症和氧化应激是升主动脉瘤形成和扩张的相关机制。纤维蛋白原与白蛋白比值反映了氧化应激和炎症。本研究旨在探讨纤维蛋白原与白蛋白比值与升主动脉瘤之间的相关性。
本研究采用综合经胸超声心动图，纳入 250 例连续升主动脉瘤患者和 250 例升主动脉直径正常的患者。比较两组间所有数据和纤维蛋白原与白蛋白比值。
与升主动脉直径正常组相比，升主动脉瘤组的纤维蛋白原与白蛋白比值水平显著升高（p<0.001）。此外，升主动脉直径与纤维蛋白原与白蛋白比值之间呈显著正相关（p<0.001）。
纤维蛋白原与白蛋白比值与升主动脉瘤相关，可作为识别高危患者的血液标志物。
