Department of Cardiovascular Surgery, Balikesir University Medical Faculty, Balıkesir, Turkey.
Department of Cardiology, Balikesir University Medical School, Balıkesir, Turkey.
J Cardiothorac Surg. 2022 Oct 4;17(1):254. doi: 10.1186/s13019-022-02003-5.
We aimed to investigate the ability of the C-reactive protein-to-albumin ratio (CAR) to predict ascending aorta progression in patients with 40-50 mm diameter of ascending aortic dilatation. A total of 182 diagnosed patients with ascending aortic diameters of 40-50 mm were enrolled in this study. The study population was divided into tertiles based on yearly ascending aortic growth rate values. Group I (n = 137) was defined as a value in the lower 2 tertiles (ascending aorta growth ≤ 1.00 mm/year), and group II (n = 45) was defined as a value in the third tertile (ascending aorta growth > 1.00 mm/year). Hypertension, chronic obstructive pulmonary disease, positive family history, and CAR were found to be independent risk factors for ascending aorta growth > 1.00 mm/year. The area under the ROC curve (AUC) of CAR was 0.771(95% CI 0.689-0.854) for predicting ascending aorta growth > 1.00 mm/year. In patients with 40-50 mm ascending aneurysms, CAR may be useful to predict ascending aorta progression.
我们旨在研究 C 反应蛋白与白蛋白比值（CAR）在预测升主动脉直径 40-50mm 的患者升主动脉进展中的能力。本研究共纳入 182 例升主动脉直径为 40-50mm 的确诊患者。根据每年升主动脉生长速度值，将研究人群分为三分位。组 I（n=137）定义为低值 2 分位（升主动脉生长速度≤1.00mm/年），组 II（n=45）定义为高值 3 分位（升主动脉生长速度>1.00mm/年）。高血压、慢性阻塞性肺疾病、阳性家族史和 CAR 是升主动脉生长速度>1.00mm/年的独立危险因素。CAR 预测升主动脉生长速度>1.00mm/年的 ROC 曲线下面积（AUC）为 0.771（95%CI 0.689-0.854）。在直径 40-50mm 的升主动脉瘤患者中，CAR 可能有助于预测升主动脉进展。
