Glyn O. Philips Hydrocolloid Research Centre at HUT, Hubei University of Technology, Wuhan, Hubei 430068, China.
Ministry-of-Education Key Laboratory for the Green Preparation and Application of Functional Materials, Hubei Key Laboratory of Polymer Materials, Hubei University, Wuhan 430062, China.
Int J Biol Macromol. 2021 Dec 15;193(Pt A):457-473. doi: 10.1016/j.ijbiomac.2021.10.142. Epub 2021 Oct 25.
Mesoporous silica nanoparticles (MSNs) have been well-researched in the design and fabrication of advanced drug delivery systems (DDSs) due to their advantages such as good biocompatibility, large specific surface area and pore volume for drug loading, easily surface modification, adjusted size and good thermal/chemical stability. For MSN-based DDSs, gate materials are also necessary. And natural polysaccharides, one kind of the most abundant natural resource, have been widely applied as the "gatekeepers" in MSN-based DDSs. Polysaccharides are cheap and rich in sources with good biocompatibility, and some of them have important biological functions. In this review article, polysaccharides including chitosan, hyaluronic acid, sodium alginate and dextran, et al. are briefly introduced. And the preparation processes and properties such as controlled drug release, cancer targeting and disease diagnosis of functional polysaccharide/MSN-based DDSs are discussed.
介孔硅纳米粒子（MSNs）由于其良好的生物相容性、大的比表面积和载药孔体积、易于表面修饰、可调的尺寸以及良好的热/化学稳定性等优点，在先进药物传递系统（DDS）的设计和制造方面得到了广泛的研究。对于基于 MSN 的 DDS，门控材料也是必需的。天然多糖作为最丰富的自然资源之一，已广泛应用于基于 MSN 的 DDS 中作为“守门员”。多糖价格便宜，来源丰富，具有良好的生物相容性，其中一些还具有重要的生物学功能。在这篇综述文章中，简要介绍了壳聚糖、透明质酸、海藻酸钠和葡聚糖等多糖。并讨论了功能性多糖/基于 MSN 的 DDS 的药物控制释放、癌症靶向和疾病诊断等特性。
