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叠氮胸苷与重组αA干扰素在体外对人类免疫缺陷病毒的协同抑制作用。

Synergistic inhibition of human immunodeficiency virus in vitro by azidothymidine and recombinant alpha A interferon.

作者信息

Hartshorn K L, Vogt M W, Chou T C, Blumberg R S, Byington R, Schooley R T, Hirsch M S

出版信息

Antimicrob Agents Chemother. 1987 Feb;31(2):168-72. doi: 10.1128/AAC.31.2.168.

DOI:10.1128/AAC.31.2.168
PMID:3471180
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC174685/
Abstract

Both recombinant alpha A interferon and azidothymidine inhibit the replication of human immunodeficiency virus in peripheral blood mononuclear cells. Combinations of recombinant alpha A interferon and azidothymidine at concentrations that are easily achievable in patients synergistically inhibit human immunodeficiency virus in vitro with minimal toxicity. Combinations of antiretroviral compounds that act by different mechanisms may prove useful in the treatment of acquired immunodeficiency syndrome-related disorders.

摘要

重组αA干扰素和齐多夫定均可抑制人类免疫缺陷病毒在外周血单核细胞中的复制。重组αA干扰素与齐多夫定以患者体内易于达到的浓度联合使用时，在体外可协同抑制人类免疫缺陷病毒，且毒性极小。作用机制不同的抗逆转录病毒化合物联合使用可能对治疗获得性免疫缺陷综合征相关疾病有用。

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Synergistic inhibition of human immunodeficiency virus in vitro by azidothymidine and recombinant alpha A interferon.叠氮胸苷与重组αA干扰素在体外对人类免疫缺陷病毒的协同抑制作用。
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本文引用的文献

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Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors.剂量-效应关系的定量分析：多种药物或酶抑制剂的联合效应
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Promising results halt trial of anti-AIDS drug.有前景的结果使抗艾滋病药物试验暂停。
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Synergistic inhibition of human T-cell lymphotropic virus type III replication in vitro by phosphonoformate and recombinant alpha-A interferon.膦甲酸盐与重组α-A干扰素在体外对人嗜T细胞病毒III型复制的协同抑制作用
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