Mazzulli T, Rusconi S, Merrill D P, D'Aquila R T, Moonis M, Chou T C, Hirsch M S
Infectious Disease Unit, Massachusetts General Hospital, Harvard Medical School, Boston 02114.
Antimicrob Agents Chemother. 1994 Apr;38(4):656-61. doi: 10.1128/AAC.38.4.656.
We compared the in vitro efficacies of two-, three-, and four-drug combinations given continuously or in alternating regimens against a clinical isolate of human immunodeficiency virus type 1. In H9 cells and peripheral blood mononuclear cells, at the drug concentrations used in this study, there was greater suppression of human immunodeficiency virus type 1 infection as the number of drugs in the regimen was increased from one to four simultaneously administered agents. Although alternating drug regimens were effective, they were not better than continuous administration of either single drugs or combinations of agents and were less effective than giving all drugs of an alternating regimen simultaneously.
我们比较了持续给药或交替给药的两种、三种和四种药物组合对1型人类免疫缺陷病毒临床分离株的体外疗效。在H9细胞和外周血单核细胞中，在本研究使用的药物浓度下，随着方案中同时给药的药物数量从一种增加到四种，对1型人类免疫缺陷病毒感染的抑制作用增强。尽管交替给药方案有效，但它们并不比单一药物或药物组合的持续给药更好，并且比同时给予交替给药方案中的所有药物效果更差。
