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96只宠物兔自发性乳腺癌中吲哚胺2,3-双加氧酶的免疫组织化学检测

Immunohistochemical Detection of Indoleamine 2,3-Dioxygenase in Spontaneous Mammary Carcinomas of 96 Pet Rabbits.

作者信息

Schöniger Sandra, Degner Sophie, Schandelmaier Claudia, Aupperle-Lellbach Heike, Zhang Qian, Schildhaus Hans-Ulrich

机构信息

Discovery Life Sciences Biomarker Services GmbH, Germaniastrasse 7, 34119 Kassel, Germany.

Institute of Veterinary Pathology, Faculty of Veterinary Medicine, Leipzig University, An den Tierkliniken 33, 04103 Leipzig, Germany.

出版信息

Animals (Basel). 2024 Jul 13;14(14):2060. doi: 10.3390/ani14142060.

DOI:10.3390/ani14142060
PMID:39061522
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11274320/
Abstract

For mammary carcinomas in pet rabbits, prognostic biomarkers are poorly defined, and treatment is limited to surgical excision. Additional treatment options are needed for rabbit patients for which surgery is not a suitable option. In human breast cancer, the immunosuppressive enzyme indoleamine 2,3-dioxygenase 1 (IDO1) represents a prognostic biomarker and possible therapeutic target. This retrospective immunohistochemical study examined IDO1 in 96 pet rabbit mammary carcinomas with known mitotic count, hormone receptor status, and percentage of stromal tumor infiltrating lymphocytes (TILs). Tumors were obtained from 96 pet rabbits with an average of 5.5 years. All rabbits with reported sex ( = 88) were female or female-spayed. Of the carcinomas, 94% expressed IDO1, and 86% had sparse TILs consistent with cold tumors. Statistically significant correlations existed between a higher percentage of IDO1-positive tumor cells, lower mitotic counts, and increased estrogen receptor expression. The threshold for significance was IDO1 staining in >10% of tumor cells. These results lead to the assumption that IDO1 expression contributes to tumorigenesis and may represent a prognostic biomarker and possible therapeutic target also in pet rabbit mammary carcinomas. They also support the value of rabbits for breast cancer research.

摘要

对于宠物兔的乳腺癌，预后生物标志物定义不明确，治疗仅限于手术切除。对于手术并非合适选择的兔患者，需要其他治疗选择。在人类乳腺癌中，免疫抑制酶吲哚胺2,3-双加氧酶1（IDO1）是一种预后生物标志物和可能的治疗靶点。这项回顾性免疫组织化学研究检测了96例已知有丝分裂计数、激素受体状态和基质肿瘤浸润淋巴细胞（TILs）百分比的宠物兔乳腺癌中的IDO1。肿瘤取自96只平均年龄为5.5岁的宠物兔。所有报告了性别的兔子（n = 88）均为雌性或已绝育雌性。在这些癌组织中，94%表达IDO1，86%有稀疏的TILs，符合冷肿瘤特征。IDO1阳性肿瘤细胞比例较高、有丝分裂计数较低和雌激素受体表达增加之间存在统计学上的显著相关性。显著性阈值为IDO1在超过10%的肿瘤细胞中染色。这些结果使人推测IDO1表达促进肿瘤发生，并且在宠物兔乳腺癌中也可能代表一种预后生物标志物和可能的治疗靶点。它们还支持兔子在乳腺癌研究中的价值。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9626/11274320/3a5f4bea5027/animals-14-02060-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9626/11274320/c29af80f7bba/animals-14-02060-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9626/11274320/950feeafc5e3/animals-14-02060-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9626/11274320/26af1da90b59/animals-14-02060-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9626/11274320/b1cd050961a4/animals-14-02060-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9626/11274320/2b9a2c5def90/animals-14-02060-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9626/11274320/c45a97fd6108/animals-14-02060-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9626/11274320/9a68c13d8b45/animals-14-02060-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9626/11274320/0f3f00be0d4c/animals-14-02060-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9626/11274320/3a5f4bea5027/animals-14-02060-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9626/11274320/c29af80f7bba/animals-14-02060-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9626/11274320/950feeafc5e3/animals-14-02060-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9626/11274320/26af1da90b59/animals-14-02060-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9626/11274320/b1cd050961a4/animals-14-02060-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9626/11274320/2b9a2c5def90/animals-14-02060-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9626/11274320/c45a97fd6108/animals-14-02060-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9626/11274320/9a68c13d8b45/animals-14-02060-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9626/11274320/0f3f00be0d4c/animals-14-02060-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9626/11274320/3a5f4bea5027/animals-14-02060-g009.jpg

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