肝细胞癌患者白细胞介素8基因多态性（-251T/A和+781C/T）的评估：一项荟萃分析。

Evaluation of interleukin 8 polymorphisms (-251T/A and +781C/T) in patients with hepatocellular carcinoma: a meta-analysis.

作者信息

Aleagha Omid Emami, Moeinzadeh Forouzan, Shokouh Seyedeh Farnaz Moeini, Doğan Erkan, Sadeghi Masoud

机构信息

Molecular Pathology Research Center, Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Clinical Research Development Center, Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran.

出版信息

Clin Exp Hepatol. 2021 Sep;7(3):278-285. doi: 10.5114/ceh.2021.109424. Epub 2021 Oct 12.

AIM OF THE STUDY

We reported the association between interleukin 8 () polymorphisms (251T/A and 781C/T) and hepatocellular carcinoma (HCC) risk in a meta-analysis.

MATERIAL AND METHODS

Scopus, PubMed, Web of Science, and Cochrane Library databases were searched until 21 November 2020. The analyses were performed by RevMan 5.3 software using odds ratios (ORs) and 95% confidence intervals (CIs). Also, the analysis of publication bias was performed by CMA 2.0 software.

RESULTS

Searching databases/sources, five articles including ten studies were entered into the meta-analysis. The pooled ORs for polymorphism were 1.07 ( = 0.55), 1.04 ( = 0.75), 1.31 ( = 0.24), 1.24 ( = 0.31), and 1.85 ( = 0.29) for allele, homozygote, heterozygote, recessive and dominant models, respectively. With regards to polymorphism, the pooled ORs were 0.74 ( = 0.07), 0.53 ( = 0.03), 0.83 ( = 0.41), 0.75 ( = 0.19), and 0.57 ( = 0.02) for allele, homozygote, heterozygote, recessive, and dominant models, respectively.

CONCLUSIONS

The findings of the meta-analysis showed a lack of significant association between (-251T/A) polymorphism and the HCC risk, whereas the TT genotype of (+781C/T) polymorphism had a protective role in HCC.

研究目的

我们在一项荟萃分析中报告了白细胞介素8（IL-8）基因多态性（251T/A和781C/T）与肝细胞癌（HCC）风险之间的关联。

材料与方法

检索Scopus、PubMed、Web of Science和Cochrane图书馆数据库直至2020年11月21日。使用RevMan 5.3软件通过比值比（OR）和95%置信区间（CI）进行分析。此外，使用CMA 2.0软件进行发表偏倚分析。

结果

通过检索数据库/来源，五项包含十项研究的文章被纳入荟萃分析。IL-8基因多态性在等位基因、纯合子、杂合子、隐性和显性模型中的合并OR分别为1.07（P = 0.55）、1.04（P = 0.75）、1.31（P = 0.24）、1.24（P = 0.31）和1.85（P = 0.29）。关于IL-8基因多态性，在等位基因、纯合子、杂合子、隐性和显性模型中的合并OR分别为0.74（P = 0.07）、0.53（P = 0.03）、0.83（P = 0.41）、0.75（P = 0.19）和0.57（P = 0.02）。