Carroll P R, Murty V V, Reuter V, Jhanwar S, Fair W R, Whitmore W F, Chaganti R S
Cancer Genet Cytogenet. 1987 Jun;26(2):253-9. doi: 10.1016/0165-4608(87)90059-8.
In an effort to determine whether or not any characteristic chromosomal abnormalities exist in renal cancer, cytogenetic findings were correlated with tumor histology in nine cases of renal adenocarcinoma. Metaphase preparations adequate for analysis were obtained from cultures harvested between day 3 and day 21. Model chromosome number was diploid in three cases, hypodiploid in three, and hyperdiploid in the remaining three. One clear cell adenocarcinoma failed to reveal any chromosomal abnormality. Two tumors, a tubular/papillary carcinoma and an acinar/papillary carcinoma, showed the clonal abnormalities del(1)(p2l),+2,+7,+8,+12,+13,+16,+17,-21 and t(2;10)(q14-21;q26),+7q,+11q,-18, respectively. Interestingly, five of six clear cell tumors studied had clonal abnormalities affecting the short arm of chromosome #3 in the 3p12-21 region, and in the remaining case, of 15 karyotyped metaphases suitable for interpretation, one showed a deletion in 3p. These data indicate that clear cell carcinoma of the kidney may be associated with a nonrandom chromosomal abnormality involving the 3p12-14 region.
为了确定肾癌中是否存在任何特征性染色体异常，对9例肾腺癌的细胞遗传学结果与肿瘤组织学进行了相关性分析。在第3天至第21天收获的培养物中获得了足以进行分析的中期染色体标本。三例的染色体模式数为二倍体，三例为亚二倍体，其余三例为超二倍体。一例透明细胞腺癌未发现任何染色体异常。两例肿瘤，一例管状/乳头状癌和一例腺泡状/乳头状癌，分别显示克隆性异常del(1)(p2l)、+2、+7、+8、+12、+13、+16、+17、-21和t(2;10)(q14-21;q26)、+7q、+11q、-18。有趣的是，所研究的6例透明细胞肿瘤中有5例在3p12-21区域存在影响3号染色体短臂的克隆性异常，在其余病例中，在15个适合分析的核型中期染色体中，有1例显示3p缺失。这些数据表明，肾透明细胞癌可能与涉及3p12-14区域的非随机染色体异常有关。
