[甲状旁腺激素及甲状旁腺激素相关肽在骨组织工程中的局部应用]
[Local administration of parathyroid hormone and parathyroid hormone-related peptides for bone tissue engineering].
作者信息
Hao Zhuowen, Li Jingfeng
机构信息
Department of Spine Surgery and Musculoskeletal Tumor, Zhongnan Hospital, Wuhan University, Wuhan 430071, P.R.China.
出版信息
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2021 Oct 25;38(5):1028-1034. doi: 10.7507/1001-5515.202104045.
Abstract
Parathyroid hormone (PTH) exerts multiple effects such as regulating bone remodeling, promoting angiogenesis, etc., and it is an active factor with great application potential for bone repair. In recent years, with the development of scaffold material loading strategies and parathyroid hormone-related peptides (PTHrPs), in situ loading of PTH or PTHrPs on scaffold materials to promote bone defect healing gradually becomes possible. Based on the current status and challenges of intermittent PTH (iPTH) for bone tissue engineering, the review summarizes the in-situ application strategies of PTH and the construction of PTHrPs as well as current problems and further directions in this field, with a view to propel the clinical application of scaffold materials loaded with PTH or PTHrPs .
摘要
甲状旁腺激素（PTH）具有多种作用，如调节骨重塑、促进血管生成等，是一种在骨修复方面具有巨大应用潜力的活性因子。近年来，随着支架材料负载策略以及甲状旁腺激素相关肽（PTHrPs）的发展，将PTH或PTHrPs原位负载于支架材料上以促进骨缺损愈合逐渐成为可能。基于间歇性PTH（iPTH）在骨组织工程中的现状与挑战，本综述总结了PTH的原位应用策略、PTHrPs的构建以及该领域目前存在的问题和未来方向，以期推动负载PTH或PTHrPs的支架材料的临床应用。
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