Sharma Shubham, Rai Vineet Kumar, Narang Raj K, Markandeywar Tanmay S
Department of Pharmaceutics, ISF College of Pharmacy, Ghal Kalan, G.T Road, Moga, Punjab 142001, India.
Department of Pharmaceutics, ISF College of Pharmacy, Ghal Kalan, G.T Road, Moga, Punjab 142001, India; IK Gujral Punjab Technical University (IKGPTU), Kapurthala Highway, Jalandhar, Punjab 144603, India.
Life Sci. 2022 Feb 1;290:120096. doi: 10.1016/j.lfs.2021.120096. Epub 2021 Oct 26.
Wounds have always been the point of concern owing to the involvement of infections and the level of severity. Therefore, the management of wounds always requires additional effort for comprehensive healing and subsequent removal of the scar from the wound site. The role of biomaterials in the management of chronic wounds has been well established. One of such biomaterials is collagen (Col) that is considered to be the crucial component of most of the formulations being developed for wound healing. The role of Col extracted from marine invertebrates remains an unmarked origin of the proteinaceous constituent in the evolution of innovative pharmaceuticals. Col is a promising, immiscible, fibrous amino acid of indigenous origin that is ubiquitously present in extracellular matrices and connective tissues. There are different types of Col present in the body such as type I, II, III, IV, and V however the natural sources of Col are vegetables and marine animals. Its physical properties like high tensile strength, adherence nature, elasticity, and remodeling contribute significantly in the wound healing process. Col containing formulations such as hydrogels, sponges, creams, peptides, and composite nanofibers have been utilized widely in wound healing and tissue engineering purposes truly as the first line of defense. Here we present the recent advancements in Col based dosage forms for wound healing. The Col based market of topical preparations and the published reports identify Colas a useful biomaterial for the delivery of pharmaceuticals and a platform for tissue engineering.
由于感染的介入和严重程度，伤口一直是人们关注的焦点。因此，伤口的处理总是需要额外的努力来实现全面愈合，并随后从伤口部位去除疤痕。生物材料在慢性伤口处理中的作用已得到充分确立。其中一种生物材料是胶原蛋白（Col），它被认为是大多数正在开发的用于伤口愈合的制剂的关键成分。从海洋无脊椎动物中提取的Col在创新药物研发中作为蛋白质成分的来源尚未得到充分关注。Col是一种有前景的、不混溶的、源自本土的纤维状氨基酸，广泛存在于细胞外基质和结缔组织中。体内存在不同类型的Col，如I型、II型、III型、IV型和V型，然而Col的天然来源是蔬菜和海洋动物。其物理特性，如高拉伸强度、粘附性、弹性和重塑能力，在伤口愈合过程中发挥着重要作用。含Col的制剂，如水凝胶、海绵、乳膏、肽和复合纳米纤维，已作为第一道防线广泛用于伤口愈合和组织工程目的。在此，我们介绍基于Col的伤口愈合剂型的最新进展。基于Col的局部制剂市场和已发表的报告表明，Col是一种用于药物递送和组织工程的有用生物材料。
