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HIV/AIDS 患儿在 HAART 治疗下的贫血症:来自埃塞俄比亚北部提格雷州梅开勒医院的横断面研究

Anemia among children living with HIV/AIDS on HAART in Mekelle Hospital, Tigray regional state of northern ethiopia - a cross-sectional study.

机构信息

Department of Medical Laboratory Science, College of Health Sciences, Mekelle University, Mekelle, Tigray, Ethiopia.

Tigray Health Research Institute, Mekelle, Tigray, Ethiopia.

出版信息

BMC Pediatr. 2021 Oct 29;21(1):480. doi: 10.1186/s12887-021-02960-1.

Abstract

BACKGROUND

Anemia is a common complication of HIV/AIDS in children. There is lack of evidence on anemia prevalence among children living with HIV/AIDS on highly active antiretroviral therapy (HAART) in Tigray regional state, which the current study aimed to generate.

METHODS

An institution-based cross-sectional study was conducted on 241 children living with HIV/AIDS on HAART attending the antiretroviral therapy (ART) clinic of Mekelle hospital from November 2018-January 2019. Socio-demographic data were collected using a structured pretested questionnaire. Participants' hemoglobin level was utilized to determine the prevalence of anemia. WHO cut-off values for Hgb were used to categorise the severity of anemia. Microscopic examination was performed for morphological classification of anemia.

RESULTS

Among the participants, 7 % (n = 16) were anemic in this study. Of these, 56 %, 19 %, and 25 % had mild, moderate, and severe anemia, respectively. Morphologically, normocytic-normochromic anemia was found the most common type of anemia in this study.

CONCLUSIONS

The prevalence of anemia among participants was low in this study. However, a considerable proportion of participants had severe anemia, requiring regular monitoring of anemia status in these patients for better clinical outcomes and quality of life improvements.

摘要

背景

贫血是儿童 HIV/AIDS 的常见并发症。在提格雷州,针对接受高效抗逆转录病毒治疗(HAART)的 HIV/AIDS 儿童贫血患病率缺乏证据,本研究旨在对此进行研究。

方法

2018 年 11 月至 2019 年 1 月,在梅开勒医院的抗逆转录病毒治疗(ART)诊所,对 241 名接受 HAART 的 HIV/AIDS 儿童进行了一项基于机构的横断面研究。使用结构化的预测试问卷收集社会人口统计学数据。参与者的血红蛋白水平用于确定贫血的患病率。世卫组织的 Hgb 临界值用于对贫血的严重程度进行分类。进行显微镜检查以对贫血进行形态学分类。

结果

在参与者中,这项研究中有 7%(n=16)贫血。其中,56%、19%和 25%分别为轻度、中度和重度贫血。在形态学上,本研究中最常见的贫血类型为正细胞正色素性贫血。

结论

在这项研究中,参与者的贫血患病率较低。然而,相当一部分参与者患有严重贫血,需要定期监测这些患者的贫血状况,以改善临床结局和提高生活质量。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b4e/8555256/4d04d6cad641/12887_2021_2960_Fig1_HTML.jpg

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