在乌干达东部高度传播恶性疟原虫的地区，疟原虫疟疾感染是发热性疾病的一个原因。
Plasmodium malariae infections as a cause of febrile disease in an area of high Plasmodium falciparum transmission intensity in Eastern Uganda.
机构信息
Infectious Diseases Research Collaboration, Kampala, Uganda.
Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.
出版信息
Malar J. 2021 Oct 29;20(1):425. doi: 10.1186/s12936-021-03962-1.
BACKGROUND
Plasmodium falciparum is responsible for the vast majority of (severe) clinical malaria cases in most African settings. Other Plasmodium species often go undiagnosed but may still have clinical consequences.
CASE PRESENTATION
Here, five cases of Plasmodium malariae infections from Eastern Uganda (aged 2-39 years) are presented. These infections were all initially mistaken for P. falciparum, but Plasmodium schizonts (up to 2080/µL) were identified by microscopy. Clinical signs included history of fever and mild anaemia.
CONCLUSION
These findings highlight the importance of considering non-falciparum species as the cause of clinical malaria. In areas of intense P. falciparum transmission, where rapid diagnostic tests that detect only P. falciparum antigens are commonly used, non-falciparum malaria cases may be missed.
背景
在大多数非洲环境中，恶性疟原虫（疟原虫的一种）导致了绝大多数（严重的）临床疟疾病例。其他疟原虫种类通常未被诊断，但仍可能有临床后果。
病例介绍
本文报告了来自乌干达东部的五例恶性疟原虫感染病例（年龄 2-39 岁）。这些感染最初都被误诊为恶性疟原虫，但通过显微镜检查发现疟原虫裂殖体（高达 2080/µL）。临床症状包括发热和轻度贫血病史。
结论
这些发现强调了将非恶性疟原虫种类视为临床疟疾病因的重要性。在恶性疟原虫传播强烈的地区，通常使用仅检测恶性疟原虫抗原的快速诊断检测方法，可能会错过非恶性疟原虫疟疾病例。
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