University of Sciences, Techniques and Technologies of Bamako, Bamako, Mali.
Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana.
Am J Trop Med Hyg. 2024 Jun 4;111(1):107-112. doi: 10.4269/ajtmh.23-0803. Print 2024 Jul 3.
Diagnostics for febrile illnesses other than malaria are not readily available in rural sub-Saharan Africa. This study assessed exposure to three mosquito-borne arboviruses-dengue virus (DENV), Zika virus (ZIKV), and chikungunya virus (CHIKV)-in southern Mali. Seroprevalence for DENV, CHIKV, and ZIKV was analyzed by detection of IgG antibodies and determined to be 77.2%, 31.2%, and 25.8%, respectively. Among study participants, 11.3% were IgG-positive for all three arboviruses. DENV had the highest seroprevalence rate at all sites; the highest seroprevalence of CHIKV and ZIKV was observed in Bamba. The seroprevalence for all three arboviruses increased with age, and the highest seroprevalence was observed among adults older than 50 years. The prevalence of Plasmodium spp. in the cohort was analyzed by microscopy and determined to be 44.5% (N = 600) with Plasmodium falciparum representing 95.1% of all infections. This study demonstrates the co-circulation of arboviruses in a region hyperendemic for malaria and highlights the needs for arbovirus diagnostics in rural sub-Saharan Africa.
在撒哈拉以南非洲农村地区，发热性疾病的诊断并不容易。本研究评估了马里南部三种蚊媒传播的虫媒病毒（登革热病毒[DENV]、寨卡病毒[ZIKV]和基孔肯雅病毒[CHIKV]）的暴露情况。通过检测 IgG 抗体分析了 DENV、CHIKV 和 ZIKV 的血清阳性率，分别为 77.2%、31.2%和 25.8%。在研究参与者中，11.3%的人对所有三种虫媒病毒的 IgG 均呈阳性。DENV 在所有地点的血清阳性率最高；Bamba 观察到 CHIKV 和 ZIKV 的血清阳性率最高。所有三种虫媒病毒的血清阳性率随年龄增长而增加，50 岁以上成年人的血清阳性率最高。通过显微镜分析了队列中疟原虫属的流行情况，确定为 44.5%（N=600），其中恶性疟原虫占所有感染的 95.1%。本研究表明，在疟疾高度流行的地区存在虫媒病毒的循环，并强调了在撒哈拉以南非洲农村地区进行虫媒病毒诊断的必要性。
