Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN.
Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN.
Semin Nephrol. 2021 Jul;41(4):349-357. doi: 10.1016/j.semnephrol.2021.06.006.
Obesity is a growing human health concern worldwide and imposes adverse effects on many cell types and organ systems, including the kidneys. Obesity interferes with various cellular processes by increasing lipid accumulation and oxidation, insulin resistance, and inflammation. Autophagy is an important cellular process to maintain hemostasis and preserve resources, but might be altered in obesity. Interestingly, experimental studies have shown either an increase or a decrease in the rate of autophagy, and accumulation of byproducts and mediators of this cascade in kidneys of obese individuals. Hence, whether autophagy is beneficial or detrimental under these conditions remains unresolved. This review summarizes emerging evidence linking superfluous fat accumulation to alterations in autophagy. Elucidating the role of autophagy in the pathogenesis and complications of obesity in the kidney might help in the identification of therapeutic targets to prevent or delay the development of chronic kidney disease in obese subjects. Autophagy, kidney, obesity, lipids.
肥胖是一个日益严重的全球人类健康问题，对包括肾脏在内的许多细胞类型和器官系统都有不良影响。肥胖通过增加脂质积累和氧化、胰岛素抵抗和炎症来干扰各种细胞过程。自噬是维持止血和保存资源的重要细胞过程，但在肥胖中可能会发生改变。有趣的是，实验研究表明，肥胖个体的肾脏中自噬的速率增加或减少，以及该级联的副产物和介质的积累。因此，自噬在这些情况下是有益还是有害仍未解决。这篇综述总结了将多余脂肪积累与自噬改变联系起来的新证据。阐明自噬在肥胖肾脏发病机制和并发症中的作用，可能有助于确定治疗靶点，以预防或延缓肥胖患者慢性肾脏病的发展。自噬；肾脏；肥胖；脂质。
