自身抗体介导的巨噬细胞反应在化脓性汗腺炎的固有和适应性免疫功能障碍之间提供了缺失的联系。
Autoantibody-Mediated Macrophage Responses Provide the Missing Link between Innate and Adaptive Immune Dysfunction in Hidradenitis Suppurativa.
机构信息
Laboratory of Translational Cutaneous Medicine, Ingham Institute of Applied Medical Research, Sydney, Australia; Department of Dermatology, Liverpool Hospital, Sydney, Australia; University of New South Wales, Sydney, Australia.
出版信息
J Invest Dermatol. 2022 Mar;142(3 Pt B):747-749. doi: 10.1016/j.jid.2021.08.400. Epub 2021 Oct 27.
Hidradenitis suppurativa is considered to be a T helper 17-mediated inflammatory disorder. However, the role of prominent B-cell and plasma cell infiltrates has not been incorporated into pathogenic understanding of the disease. In their new article in the Journal of Investigative Dermatology, Carmona-Rivera et al. (2021) present new insights regarding autoantibody-mediated macrophage activation, which bridges the link between the innate and adaptive immune responses in severe hidradenitis suppurativa.
化脓性汗腺炎被认为是一种辅助性 T 细胞 17 介导的炎症性疾病。然而，显著的 B 细胞和浆细胞浸润的作用尚未被纳入对该疾病发病机制的理解中。在他们发表于《皮肤病学研究杂志》的新文章中，Carmona-Rivera 等人（2021 年）提出了关于自身抗体介导的巨噬细胞激活的新见解，这一发现架起了严重化脓性汗腺炎固有免疫和适应性免疫反应之间的桥梁。
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