Shen Xue, Peng Chuangang, Zhao Yan, Zhong Lili, Cai Hanqing, Kan Bo, Zhang Yuzheng, Xue Shanshan, Qiao Wenjing, Zhao Qianqian, Guo Dingjie, Li Binbin, Vuong Ann M, Yang Shuman
Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun, Jilin, China.
Department of Orthopaedics, The Second Hospital of Jilin University, Changchun, Jilin, China.
J Clin Densitom. 2022 Apr-Jun;25(2):141-149. doi: 10.1016/j.jocd.2021.09.003. Epub 2021 Sep 25.
In vitro and vivo studies indicate that oxidative stress contributes to bone loss. Fluorescent oxidation products (FlOPs) are novel biomarkers of oxidative stress; they reflect global oxidative damage of lipids, proteins, carbohydrates, and DNA. However, whether FlOPs are associated with bone mineral density (BMD) is still unclear. In the present study, we examined the association between FlOPs and BMD among male veterans. This cross-sectional study was conducted among participants recruited from the Department of Medical Examination, The Second Hospital of Jilin University in Jilin, China. We identified male veterans who were at least 50 y old between June and October of 2019. Plasma FlOPs were measured with a fluorescent microplate reader (excitation/emission wavelength: 320/420 nm). BMD were measured by dual-energy X-ray absorptiometry (DXA). The association between FlOPs and BMD was tested by multivariable linear regression models. A total of 164 male veterans were enrolled in the study, the average age was 56.6 y. After adjusting for covariates, veterans who had FlOP levels in the highest tertile had a statistically significant lower femoral neck (β = -0.044; p = 0.007) and total hip BMD (β = -0.045; p = 0.020) as compared to those with FlOP levels in the lowest tertile. Similar results were found when FlOPs were treated as a continuous variable (per 1-SD increase, β = -0.014 and p = 0.033 for femoral neck BMD; β = -0.016 and p = 0.047 for total hip BMD). Higher FlOP levels were associated with lower BMD among male veterans.
体外和体内研究表明，氧化应激会导致骨质流失。荧光氧化产物（FlOPs）是氧化应激的新型生物标志物；它们反映了脂质、蛋白质、碳水化合物和DNA的整体氧化损伤。然而，FlOPs是否与骨密度（BMD）相关仍不清楚。在本研究中，我们调查了男性退伍军人中FlOPs与BMD之间的关联。这项横断面研究是在中国吉林省吉林大学第二医院体检科招募的参与者中进行的。我们确定了在2019年6月至10月期间年龄至少为50岁的男性退伍军人。使用荧光酶标仪（激发/发射波长：320/420 nm）测量血浆FlOPs。通过双能X线吸收法（DXA）测量BMD。通过多变量线性回归模型测试FlOPs与BMD之间的关联。共有164名男性退伍军人参与了本研究，平均年龄为56.6岁。在调整协变量后，与FlOP水平处于最低三分位数的退伍军人相比，FlOP水平处于最高三分位数的退伍军人的股骨颈骨密度（β = -0.044；p = 0.007）和全髋骨密度（β = -0.045；p = 0.020）在统计学上显著更低。当将FlOPs视为连续变量时也发现了类似结果（股骨颈骨密度每增加1个标准差，β = -0.014，p = 0.033；全髋骨密度每增加1个标准差，β = -0.016，p = 0.047）。在男性退伍军人中，较高的FlOP水平与较低的BMD相关。
