Psychiatric Hospital "Sveti Ivan", Jankomir 11, 10090 Zagreb, Croatia,
Psychiatr Danub. 2021 Spring-Summer;33(Suppl 4):596-603.
The aim of this research was to determine which of two chosen questionnaires for subjective symptoms of dry eye (Ocular Surface Disease Index and Schein questionnaire) is more reliable in the assessment of dry eye in patients with schizophrenia.
Our research included 80 patients (160 eyes) of both sexes with schizophrenia ranging between the age of 25 and 55 who have been taking one of three antipsychotic drugs namely clozapin, olanzapin, quetiapin for five or more years and were in a stable phase of the disease or remission. All participants were required to satisfy all included and excluded criteria. They all filled out the Schein and OSDI questionnaires for assessment of subjective symptoms. Tear break-up time test (TBUT) for objective evaluation of tear film stability was also performed. In order to determine the correlation between two subjective and objective tests we calculated Spearmans correlation coefficients.
Obtained results of the correlation between OSDI questionnaire and TBUT test for the right eye was r=-0.73; p<0.01 and for the left eye was r=-0.72; p<0.01. Results of the correlation between Schein questionnaire and TBUT test for the right eye was r=-0.62; p<0.01 and for the left eye was r=-0.60; p<0.01. A detailed analysis shows that there are no statistically significant differences between the correlations. Both subjective questionnaires are statistically significantly and negatively related to the TBUT test, showing that an increase in the results on the OSDI and Schein's questionnaires led to the decreases in the results on the TBUT test.
In patients with schizophrenia the OSDI and Schein questionnaires are equally reliable in the assessment of subjective symptoms of Dry eye disease. Considering that, OSDI is more common in clinical practice and includes questions regarding quality of life, it would have certain advantages and it is recommended for use in patients with schizophrenia.
本研究旨在确定两种选择的干眼主观症状问卷（眼表面疾病指数和 Schein 问卷）中哪一种在评估精神分裂症患者的干眼方面更可靠。
我们的研究包括 80 名（160 只眼）年龄在 25 至 55 岁之间的男女精神分裂症患者，他们服用三种抗精神病药物中的一种，即氯氮平、奥氮平、喹硫平，已超过 5 年，且处于疾病稳定期或缓解期。所有参与者均需符合所有纳入和排除标准。他们都填写了 Schein 和 OSDI 问卷以评估主观症状。还进行了泪膜破裂时间测试（TBUT）以客观评估泪膜稳定性。为了确定两种主观和客观测试之间的相关性，我们计算了 Spearmans 相关系数。
右眼 OSDI 问卷与 TBUT 测试之间的相关性结果为 r=-0.73;p<0.01，左眼为 r=-0.72;p<0.01。Schein 问卷与 TBUT 测试之间的相关性结果右眼为 r=-0.62;p<0.01，左眼为 r=-0.60;p<0.01。详细分析表明，这些相关性之间没有统计学上的显著差异。两种主观问卷均与 TBUT 测试呈统计学显著负相关，表明 OSDI 和 Schein 问卷的结果增加会导致 TBUT 测试的结果降低。
在精神分裂症患者中，OSDI 和 Schein 问卷在评估干眼疾病的主观症状方面同样可靠。考虑到 OSDI 在临床实践中更为常见且包含有关生活质量的问题，它具有一定的优势，建议在精神分裂症患者中使用。
