金催化酰胺-炔烃的氧化环化反应：构建功能化的γ-内酰胺。
Gold-catalyzed oxidative cyclization of amide-alkynes: access to functionalized γ-lactams.
机构信息
College of Sciences, Henan Agricultural University, Zhengzhou 450002, China.
出版信息
Org Biomol Chem. 2021 Nov 18;19(44):9688-9691. doi: 10.1039/d1ob01846a.
PMID:34718364
Abstract
An efficient gold-catalyzed oxidative cyclization of amide-alkynes is developed. A series of functionalized γ-lactams are easily accessed by employing this strategy. The tandem reaction proceeds through alkyne oxidation, carbene/alkyne metathesis, and donor/donor carbene oxidation.
摘要
发展了一种高效的金催化酰胺-炔烃的氧化环化反应。该策略可用于合成一系列功能化的γ-内酰胺。串联反应通过炔烃氧化、卡宾/炔烃交叉复分解和给体/给体卡宾氧化进行。
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