Challenges in Translating Clinical Metabolomics Data Sets from the Bench to the Bedside.
作者信息
Ulmer Candice Z, Maus Anthony, Hines Jolaine, Singh Ravinder
机构信息
Clinical Chemistry Branch, Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
出版信息
Clin Chem. 2021 Nov 26;67(12):1581-1583. doi: 10.1093/clinchem/hvab210.
Abstract
摘要
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Rapid Commun Mass Spectrom. 2021 Jan 30;35(2):e8977. doi: 10.1002/rcm.8977.
2
Metabolomics for laboratory diagnostics.用于实验室诊断的代谢组学。
J Pharm Biomed Anal. 2015 Sep 10;113:108-20. doi: 10.1016/j.jpba.2014.12.017. Epub 2014 Dec 25.
3
Monitoring phospholipids for assessment of ion enhancement and ion suppression in ESI and APCI LC/MS/MS for chlorpheniramine in human plasma and the importance of multiple source matrix effect evaluations.监测磷脂以评估人血浆中氯苯那敏在电喷雾电离（ESI）和大气压化学电离（APCI）液相色谱/串联质谱（LC/MS/MS）中的离子增强和离子抑制作用以及多源基质效应评估的重要性。
J Chromatogr B Analyt Technol Biomed Life Sci. 2008 Nov 15;875(2):333-43. doi: 10.1016/j.jchromb.2008.08.032. Epub 2008 Sep 18.
4
Strategies for the assessment of matrix effect in quantitative bioanalytical methods based on HPLC-MS/MS.基于高效液相色谱-串联质谱法的定量生物分析方法中基质效应评估策略。
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5
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