Falkner B, Kushner H, Khalsa D K, Canessa M, Katz S
J Hypertens Suppl. 1986 Dec;4(5):S381-3.
The response to chronic oral sodium loading was studied in young adult (18-23 years) blacks. A representative sample of participants (n=40) from previous longitudinal studies had growth measures at age 6-7 years and 11-16 years. Blood pressure, weight and stress-induced reactivity were measured before and after 14 days of 10 g NaCl daily added to the usual diet. A sodium-sensitive response (SS) was an increase in mean arterial pressure (MAP) greater than or equal to 5 mmHg. A sodium-insensitive response (S) was an increase in MAP less than or equal to 5 mmHg. Family history of hypertension (FH+) was determined by self-report. Fifty-three per cent were SS. There were no difference in age-related BP, weight or height between SS and SI in childhood or adolescence. Those with a family history of hypertension had a greater BP response to stress and greater weight change with sodium load. The group which was both SS and FH+ had the highest weight and MAP stress response after sodium load. These results indicate that sodium sensitivity is high among blacks, but does not correlate with childhood growth variables. Sodium sensitivity and FH+ combined produce the greatest stress-induced BP response.
在年轻成年（18 - 23岁）黑人中研究了对慢性口服钠负荷的反应。来自先前纵向研究的参与者代表性样本（n = 40）在6 - 7岁和11 - 16岁时进行了生长测量。在将每日10克氯化钠添加到日常饮食中14天前后，测量血压、体重和应激诱导反应性。钠敏感反应（SS）是平均动脉压（MAP）升高大于或等于5 mmHg。钠不敏感反应（S）是MAP升高小于或等于5 mmHg。高血压家族史（FH +）通过自我报告确定。53%为SS。在儿童期或青春期，SS和SI之间在与年龄相关的血压、体重或身高方面没有差异。有高血压家族史的人对应激的血压反应更大，并且钠负荷后体重变化更大。既是SS又是FH +的组在钠负荷后体重和MAP应激反应最高。这些结果表明黑人中钠敏感性较高，但与儿童生长变量无关。钠敏感性和FH +相结合产生最大的应激诱导血压反应。
