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哪些因素导致全膝关节置换术后聚乙烯磨损?:一项大型检索系列研究结果。

What factors drive polyethylene wear in total knee arthroplasty? : results of a large retrieval series.

机构信息

Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire, USA.

Department of Orthopedic Surgery, Mayo Clinic, Rochester, Minnesota, USA.

出版信息

Bone Joint J. 2021 Nov;103-B(11):1695-1701. doi: 10.1302/0301-620X.103B11.BJJ-2020-2334.R1.

DOI:10.1302/0301-620X.103B11.BJJ-2020-2334.R1
PMID:34719265
Abstract

AIMS

Wear of the polyethylene (PE) tibial insert of total knee arthroplasty (TKA) increases the risk of revision surgery with a significant cost burden on the healthcare system. This study quantifies wear performance of tibial inserts in a large and diverse series of retrieved TKAs to evaluate the effect of factors related to the patient, knee design, and bearing material on tibial insert wear performance.

METHODS

An institutional review board-approved retrieval archive was surveyed for modular PE tibial inserts over a range of in vivo duration (mean 58 months (0 to 290)). Five knee designs, totalling 1,585 devices, were studied. Insert wear was estimated from measured thickness change using a previously published method. Linear regression statistical analyses were used to test association of 12 patient and implant design variables with calculated wear rate.

RESULTS

Five patient-specific variables and seven implant-specific variables were evaluated for significant association with lower insert wear rate. Six were significant when controlling for other factors: greater patient age, female sex, shorter duration in vivo, polished tray, highly cross-linked PE (HXLPE), and constrained knee design.

CONCLUSION

This study confirmed that knee wear rate increased with duration in vivo. Older patients and females had significantly lower wear rates. Polished modular tibial tray surfaces, HXLPE, and constrained TKA designs were device design factors associated with significantly reduced wear rate. Cite this article:  2021;103-B(11):1695-1701.

摘要

目的

全膝关节置换术(TKA)中聚乙烯(PE)胫骨衬垫的磨损会增加翻修手术的风险,并给医疗保健系统带来巨大的经济负担。本研究通过对大量不同类型的 TKA 取出物进行分析,量化了胫骨衬垫的磨损性能,以评估与患者、膝关节设计和轴承材料相关的因素对胫骨衬垫磨损性能的影响。

方法

对一个机构审查委员会批准的检索档案进行调查,以确定各种体内持续时间(平均 58 个月(0 至 290 个月))的模块化 PE 胫骨衬垫。研究了五种膝关节设计,共 1585 个装置。使用先前发表的方法,通过测量厚度变化来估计插入物的磨损。线性回归统计分析用于测试 12 个患者和植入物设计变量与计算磨损率之间的关联。

结果

对五个患者特定变量和七个植入物特定变量进行了评估,以确定它们与较低的插入物磨损率之间的关联。当控制其他因素时,有六个变量具有显著意义:患者年龄较大、女性、体内持续时间较短、抛光托盘、高度交联 PE(HXLPE)和约束性膝关节设计。

结论

本研究证实,膝关节的磨损率随体内持续时间的增加而增加。年龄较大的患者和女性的磨损率明显较低。抛光的模块化胫骨托盘表面、HXLPE 和约束性 TKA 设计是与显著降低磨损率相关的设备设计因素。

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