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2-氰基丙烯酸酯衍生物的农药活性研究进展。

Recent Advances in the Pesticide Activities of 2-Cyanoacrylate Derivatives.

机构信息

State Key Laboratory of Elemento-Organic Chemistry, Research Institute of Elemento-Organic Chemistry, College of Chemistry, Frontiers Science Center for New Organic Matter, Nankai University, Tianjin 300071, People's Republic of China.

出版信息

J Agric Food Chem. 2021 Nov 10;69(44):12933-12946. doi: 10.1021/acs.jafc.1c04953. Epub 2021 Nov 1.

Abstract

2-Cyanoacrylates are a unique class of compounds with high photosystem II electron transport inhibitory activity. Through the in-depth study of molecular design, synthesis, biological activity, structure-activity relationship, and action mechanism, a large number of 2-cyanoacrylate derivatives with excellent herbicidal activity were found. In addition, 2-cyanoacrylate derivatives with different substituents have also been found to have good fungicidal or anti-plant virus activities. To further guide the design and development of new pesticide candidates, the representative research work of 2-cyanoacrylate derivatives with herbicidal, fungicidal, and anti-plant virus activities was reviewed.

摘要

2-氰基丙烯酸酯是一类具有高光合系统 II 电子传递抑制活性的独特化合物。通过深入研究分子设计、合成、生物活性、构效关系和作用机制,发现了大量具有优异除草活性的 2-氰基丙烯酸酯衍生物。此外,还发现具有不同取代基的 2-氰基丙烯酸酯衍生物具有良好的杀菌或抗植物病毒活性。为了进一步指导新型农药候选物的设计和开发,综述了具有除草、杀菌和抗植物病毒活性的 2-氰基丙烯酸酯衍生物的代表性研究工作。

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