Tianjin Key Laboratory of Drug Targeting & Bioimaging, Tianjin Enterprise Key Laboratory for Application Research of Hyaluronic Acid, School of Chemistry & Chemical Engineering, Tianjin University of Technology, Tianjin, China.
State Key Laboratory of Separation Membranes & Membrane Processes, School of Materials Science & Engineering, Tiangong University, Tianjin, 300384, China.
Nanomedicine (Lond). 2021 Dec;16(29):2587-2604. doi: 10.2217/nnm-2021-0329. Epub 2021 Nov 1.
The authors aimed to develop Dox@Rg1 nanoparticles with decreased cardiotoxicity to expand their application in cancer. Dox@Rg1 nanoparticles were developed by encapsulating doxorubicin (Dox) in a self-assembled Rg1. The antitumor effect of the nanoparticles was estimated using 4T1 tumor-bearing mice and the protective effect on the heart was investigated and . Different from Dox, the Dox@Rg1 nanoparticles induced increased cytotoxicity to tumor cells, which was decreased in cardiomyocytes by the inhibition of apoptosis. The study revealed that the Dox@Rg1 nanoparticles presented a perfect tumor-targeting ability and improved antitumor effects. Dox@Rg1 nanoparticles could enhance the antitumor effects and decrease the cardiotoxicity of Dox.
作者旨在开发具有降低心脏毒性的 Dox@Rg1 纳米粒，以拓展其在癌症治疗中的应用。Dox@Rg1 纳米粒是通过将阿霉素（Dox）包裹在自组装的 Rg1 中而开发的。使用 4T1 荷瘤小鼠评估了纳米粒的抗肿瘤作用，并研究了其对心脏的保护作用。与 Dox 不同，Dox@Rg1 纳米粒诱导肿瘤细胞的细胞毒性增加，而通过抑制细胞凋亡，在心肌细胞中则降低。该研究表明，Dox@Rg1 纳米粒具有完美的肿瘤靶向能力和增强的抗肿瘤效果。Dox@Rg1 纳米粒可以增强 Dox 的抗肿瘤效果并降低其心脏毒性。
