Rao Guttikonda Venkateshwara, Preethi Vem, Daneswari Velagala, Reddy Venugopal, Sivakalyan Venumbaka, Garge Rajesh
Department of Oral Pathology, Mamata Dental College and Hospital, Khammam, Telangana, India.
Department of Pedodontics and Preventive Dentistry, Mamata Dental College and Hospital, Khammam, Telangana, India.
Int J Clin Pediatr Dent. 2021 May-Jun;14(3):342-348. doi: 10.5005/jp-journals-10005-1955.
Thalassemia is a genetically diverse group of disease which occurs due to an imbalance in the production of the alpha and beta chains with ensuring chronic hemolysis, ineffective erythropoiesis, and iron overload.
The main aim of the study is to compare the salivary flow rate, pH, buffer capacity, total antioxidant capacity, and ferritin levels in children with beta thalassemia major and healthy children.
The present study includes 40 children consisting of 20 beta thalassemia major and 20 healthy children. Unstimulated saliva was collected by the spitting method. The salivary flow rate, pH, buffer capacity, total antioxidant capacity, and ferritin levels were evaluated.
Salivary ferritin levels were found to be higher in children with beta thalassemia major.
Iron overload is also known as hemochromatosis which is one of the complications of thalassemia.
Rao GV, Preethi V, Daneswari V, . A Comparative Study of Salivary Flow Rate, pH, Buffer Capacity, Total Antioxidant Capacity, and Ferritin Levels in Children with Beta Thalassemia Major and Healthy Children. Int J Clin Pediatr Dent 2021;14(3):342-348.
地中海贫血是一组具有遗传多样性的疾病，由于α链和β链生成失衡，导致慢性溶血、无效红细胞生成和铁过载。
本研究的主要目的是比较重型β地中海贫血患儿和健康儿童的唾液流速、pH值、缓冲能力、总抗氧化能力和铁蛋白水平。
本研究纳入40名儿童，其中20名重型β地中海贫血患儿和20名健康儿童。采用吐唾法收集非刺激性唾液。评估唾液流速、pH值、缓冲能力、总抗氧化能力和铁蛋白水平。
发现重型β地中海贫血患儿的唾液铁蛋白水平较高。
铁过载也称为血色素沉着症，是地中海贫血的并发症之一。
Rao GV, Preethi V, Daneswari V, 。重型β地中海贫血患儿和健康儿童唾液流速、pH值、缓冲能力、总抗氧化能力和铁蛋白水平的比较研究。《国际临床儿科牙科学杂志》2021年；14(3):342 - 348。
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