Zewudie Bitew Tefera, Geze Shegaw, Mesfin Yibeltal, Argaw Muche, Abebe Haimanot, Mekonnen Zebene, Tesfa Shegaw, Chekole Bogale, Tadesse Betelhem, Aynalem Agere, Lankrew Tadele
Department of Nursing, College of Medicine and Health Science, Wolkite University, Wolkite, Ethiopia.
Department of Midwifery, College of Medicine and Health Science, Wolkite University, Wolkite, Ethiopia.
Depress Res Treat. 2021 Oct 20;2021:8545934. doi: 10.1155/2021/8545934. eCollection 2021.
Depression is the most common mental health problem in people living with the human immune virus. It ranges from 11% to 63% in low- and middle-income countries. Depression was high in people living with HIV/AIDS in developing countries, especially in the Ethiopian context. Even though depression has negative consequences on HIV-positive patients, the care given for depression in resource-limited countries like Ethiopia is below the standard in their HIV care programs.
International databases (Google Scholar, PubMed, Hinari, Embase, and Scopus) and Ethiopian university repository online have been covered in this review. Data were extracted using Microsoft Excel and analyzed by using the Stata version 14 software program. We detected the heterogeneity between studies using the test. We checked publication bias using a funnel plot test.
The overall pooled depression prevalence among adult HIV/AIDS patients attending antiretroviral therapy in Ethiopia was 36.3% (95% CI: 28.4%, 44.2%) based on the random effect analysis. Adult HIV/AIDS patients having CD4count < 200(AOR = 5.1; 95% CI: 2.89, 8.99), widowed marital status (AOR = 3.7; 95% CI: 2.394, 5.789), medication nonadherence (AOR = 2.3; 95% CI: 1.63, 3.15), poor social support (2.986) (95% CI: 2.139, 4.169), perceived social stigma (2.938) (2.305, 3.743), opportunistic infections (3.010) (2.182, 4.151), and adverse drug reactions (4.013) (1.971, 8.167) were significantly associated with depression among adult HIV/AIDS patients on antiretroviral therapy, in Ethiopia. . The pooled depression prevalence among adult HIV/AIDS patients attending antiretroviral therapy in Ethiopia was higher than the general population and is alarming for the government to take special consideration for HIV-positive patients. Depression assessment for all HIV-positive patients and integrating with mental health should be incorporated to ensure early detection, prevention, and treatment. Community-based and longitudinal study designs mainly focusing on the incidence and determinants of depression among adult HIV/AIDS patients should be done in the future.
抑郁症是感染人类免疫病毒人群中最常见的心理健康问题。在低收入和中等收入国家，其发病率在11%至63%之间。在发展中国家，尤其是在埃塞俄比亚的背景下，感染艾滋病毒/艾滋病的人群中抑郁症发病率很高。尽管抑郁症对艾滋病毒呈阳性的患者有负面影响，但在像埃塞俄比亚这样资源有限的国家，针对抑郁症的护理在其艾滋病毒护理项目中未达标准。
本综述涵盖了国际数据库（谷歌学术、PubMed、Hinari、Embase和Scopus）以及埃塞俄比亚大学在线知识库。数据使用Microsoft Excel提取，并使用Stata 14软件程序进行分析。我们使用 检验检测研究之间的异质性。我们使用漏斗图检验检查发表偏倚。
根据随机效应分析，在埃塞俄比亚接受抗逆转录病毒治疗的成年艾滋病毒/艾滋病患者中，抑郁症的总体合并患病率为36.3%（95%置信区间：28.4%，44.2%）。CD4细胞计数<200的成年艾滋病毒/艾滋病患者（优势比=5.1；95%置信区间：2.89，8.99）、丧偶婚姻状况（优势比=3.7；95%置信区间：2.394，5.789）、药物治疗不依从（优势比=2.3；95%置信区间：1.63，3.15）、社会支持不足（2.986）（95%置信区间：2.139，4.169）、感知到的社会耻辱感（2.938）（2.305，3.743）、机会性感染（3.010）（2.182，4.151）和药物不良反应（4.013）（1.971，8.167）与埃塞俄比亚接受抗逆转录病毒治疗的成年艾滋病毒/艾滋病患者的抑郁症显著相关。埃塞俄比亚接受抗逆转录病毒治疗的成年艾滋病毒/艾滋病患者中抑郁症的合并患病率高于普通人群。这警示政府要对艾滋病毒呈阳性的患者给予特别关注。应将对所有艾滋病毒呈阳性患者的抑郁症评估以及与心理健康相结合纳入其中，以确保早期发现、预防和治疗。未来应开展主要关注成年艾滋病毒/艾滋病患者抑郁症发病率和决定因素的基于社区的纵向研究设计。
