秘鲁利马，中老年艾滋病毒感染者的抑郁风险因素。
Risk Factors for Depression Among Middle-Aged to Older People Living With HIV in Lima, Peru.
机构信息
Department of Epidemiology, Universidad San Ignacio de Loyola, Lima, Peru.
Department of Neurology, Northwestern University School of Medicine, Chicago, IL, USA.
出版信息
J Int Assoc Provid AIDS Care. 2024 Jan-Dec;23:23259582241273452. doi: 10.1177/23259582241273452.
INTRODUCTION
Depression is prevalent among aging people living with HIV (PLWH) worldwide. We sought to identify depression risk factors among a group of middle-aged and older PLWH in Lima, Peru.
MATERIALS AND METHODS
We assessed risk factors for depression among PLWH over age 40 receiving care in an HIV clinic in Lima, Peru. The Patient Health Questionnaire-9 (PHQ-9) was administered. We performed descriptive statistics and logistic regression analyses.
RESULTS
Mean age was 51.7 ± 7.7 years with 15.3% females. One-quarter of participants had depression with higher frequency in females. Risk factors that significantly increased the risk of depression included female sex (adjusted prevalence ratio [aPR] = 2.19 [95%CI 1.07-4.49]), currently smoking (aPR = 2.25 [95%CI 1.15-4.43]), and prior opportunistic infection (aPR = 2.24 [95%CI 1.05-4.76]).
DISCUSSION
Our study demonstrates that PLWH who are female, current smokers, or had an opportunistic infection have higher risk of depression. Identifying PLWH at-risk for depression is key to early mental health interventions.
简介
全球范围内，艾滋病病毒（HIV）感染者（PLWH）中老年人抑郁的发病率较高。我们旨在确定秘鲁利马的一组中年及以上 PLWH 中抑郁的风险因素。
材料与方法
我们评估了在秘鲁利马的一家 HIV 诊所接受治疗的 40 岁以上 PLWH 中与抑郁相关的风险因素。采用患者健康问卷-9（PHQ-9）进行评估。我们进行了描述性统计和逻辑回归分析。
结果
平均年龄为 51.7±7.7 岁，女性占 15.3%。四分之一的参与者患有抑郁症，女性中发病率更高。显著增加抑郁风险的因素包括女性（调整后患病率比[aPR] = 2.19[95%CI 1.07-4.49]）、当前吸烟（aPR = 2.25[95%CI 1.15-4.43]）和既往机会性感染（aPR = 2.24[95%CI 1.05-4.76]）。
讨论
我们的研究表明，女性、当前吸烟者或患有机会性感染的 PLWH 患抑郁的风险更高。识别出有抑郁风险的 PLWH 是早期心理健康干预的关键。
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