The Protective Effect of on Infection Induced Damage to Intestinal Mucosa.

Intensive farming is prone to induce large-scale outbreaks of infectious diseases, with increasing use of antibiotics, which deviate from the demand of organic farming. The high mortality rate of chickens infected with caused huge economic losses; therefore, the promising safe prevention and treatment measures of are in urgent need, such as probiotics. Probiotics are becoming an ideal alternative treatment option besides antibiotics, but the effective chicken probiotic strains with clear protective mechanism against remain unclear. In this study, we found YQH2 was effective in preventing infection in chickens. induced the loss of body weight, and liver and intestinal morphology damage. The inflammatory factor levels increased and intestinal proliferation inhibited. However, after treatment with YQH2, broilers grew normally, the pathological changes of liver and intestine were reduced, and the colonization of in the intestine was improved. Not only that, the length of villi and the depth of crypts were relatively normal, and the levels of inflammatory factors such as IL-1β, TNF-α, and IL-8 were reduced. The number of PCNA cells of YQH2 returned to normal under the action of infection, which was conducive to the normal proliferation of intestinal epithelial cells. The protective effect of YQH2 may be due to the attribution to the activation of hypoxia and then induced the proliferation of intestinal stem cells to repair the damage of intestinal mucosa under infection. This study demonstrated that YQH2 was effective in preventing infection, which could be further used in the chicken health breeding.