Jin Fei-Qin, Jin Lei, Wang Yan-Ling
Department of Radiology, People's Hospital of Gaoxin District, Suzhou, 215129, Jiangsu, China.
Department of Neurosurgery, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 510000, Guangdong, China.
Open Life Sci. 2021 Oct 25;16(1):1164-1174. doi: 10.1515/biol-2021-0119. eCollection 2021.
is a winged helix transcription factor structurally and functionally related to the forkhead family of transcription factors. Recent studies have highlighted its role in the central nervous system and revealed hints in the development of glioma. However, the expression profiles of , its association with clinicopathological characteristics, and potential functions in glioma remain unknown. In this study, we analyzed three publicly available datasets including CGGA, TCGA, and Rembrandt and revealed a grade-dependent reduction in expression in glioma ( < 0.001). Chi-square test demonstrated that low expression was significantly associated with older age at initial diagnosis ( < 0.001), less IDH1 mutation ( < 0.001), and advanced WHO grade ( < 0.001). Moreover, multivariate Cox regression analysis showed that expression may serve as a novel independent prognostic biomarker in glioma patients. Bioinformatic functional analysis (GSEA) predicted that was related to many key cancer pathways including P53 signaling pathway ( < 0.01), DNA replication ( < 0.05), homologous recombination ( < 0.05), and Wnt signaling pathway ( < 0.05). Taken together, these findings suggested that may be used as a novel predictive molecular biomarker for glioma grading and overall patient survival. Further investigations on the functional roles and therapeutic value of in glioma are warranted.
是一种与叉头转录因子家族在结构和功能上相关的翼状螺旋转录因子。最近的研究突出了其在中枢神经系统中的作用，并揭示了在胶质瘤发生发展中的一些线索。然而，其表达谱、与临床病理特征的关联以及在胶质瘤中的潜在功能仍不清楚。在本研究中，我们分析了三个公开可用的数据集，包括CGGA、TCGA和Rembrandt，并揭示了胶质瘤中表达随分级降低（<0.001）。卡方检验表明，低表达与初次诊断时年龄较大（<0.001）、IDH1突变较少（<0.001）以及WHO高级别（<0.001）显著相关。此外，多变量Cox回归分析表明，表达可能作为胶质瘤患者一种新的独立预后生物标志物。生物信息功能分析（GSEA）预测与许多关键癌症通路相关，包括P53信号通路（<0.01）、DNA复制（<0.05）、同源重组（<0.05）和Wnt信号通路（<0.05）。综上所述，这些发现表明可作为胶质瘤分级和患者总体生存的一种新的预测分子生物标志物。有必要对其在胶质瘤中的功能作用和治疗价值进行进一步研究。
