Shenzhen Key Laboratory of Smart Healthcare Engineering, Department of Biomedical Engineering, Southern University of Science and Technology, No. 1088 Xueyuan Road, Nanshan District, Shenzhen, Guangdong 518055, China.
GBA Research Innovation Institute for Nanotechnology, CAS Key Lab for Biological Effects of Nanomaterials and Nanosafety, National Center for NanoScience and Technology, Beijing 100190, China.
ACS Nano. 2021 Nov 23;15(11):17885-17894. doi: 10.1021/acsnano.1c06139. Epub 2021 Nov 1.
The replacement of dressings may cause secondary damage to the wounds; thus, the real-time monitoring of the state of wound dressings is crucial for evaluating wound care processes. Herein, we report a smart dressing to self-monitor residue nanomedicine on it during the application. We load aminobenzeneboronic acid (ABA)-modified gold nanoclusters (A-GNCs) on bacterial cellulose (BC) membranes as an antibacterial wound dressing to display the amount of residual nanomedicine (A-GNCs) by colorimetry during the application in remedying multi-drug-resistant (MDR) bacteria-infected wounds. A-GNCs emit bright orange fluorescence under UV light, whereas the BC membrane is transparent at a humidified state on the wounds. Thus, the BC-A-GNCs nanocomposite (BGN) shows decreasing intensity of orange fluorescence with the release of the A-GNCs, indicating the appropriate time points for the replacement of the dressing. The BGN, which can realize accurate self-monitoring in a simple, low-cost, and efficient way, thus holds great promise for broad clinical applications.
更换敷料可能会对伤口造成二次伤害；因此，实时监测伤口敷料的状态对于评估伤口护理过程至关重要。在这里，我们报告了一种智能敷料，可在使用过程中自行监测其表面残留纳米药物。我们将氨基苯硼酸（ABA）修饰的金纳米簇（A-GNCs）负载在细菌纤维素（BC）膜上作为一种具有抗菌作用的伤口敷料，通过比色法显示在治疗多重耐药（MDR）细菌感染伤口过程中残留纳米药物（A-GNCs）的量。A-GNCs 在紫外线下发出明亮的橙色荧光，而在湿润状态下的 BC 膜在伤口上是透明的。因此，BC-A-GNCs 纳米复合材料（BGN）随着 A-GNCs 的释放，其橙色荧光强度逐渐降低，表明敷料更换的合适时间点。BGN 可以以简单、低成本和高效的方式实现准确的自我监测，因此在广泛的临床应用中具有很大的应用前景。
