用于治疗 COVID-19 的植物化学物质。
Phytochemicals for the treatment of COVID-19.
机构信息
Department of Pharmacy, Korea University College of Pharmacy, Sejong, 30019, Republic of Korea.
出版信息
J Microbiol. 2021 Nov;59(11):959-977. doi: 10.1007/s12275-021-1467-z. Epub 2021 Nov 1.
Abstract
The coronavirus disease 2019 (COVID-19) pandemic has underscored the lack of approved drugs against acute viral diseases. Plants are considered inexhaustible sources of drugs for several diseases and clinical conditions, but plant-derived compounds have seen little success in the field of antivirals. Here, we present the case for the use of compounds from vascular plants, including alkaloids, flavonoids, polyphenols, and tannins, as antivirals, particularly for the treatment of COVID-19. We review current evidence for the use of these phytochemicals against SARS-CoV-2 infection and present their potential targets in the SARS-CoV-2 replication cycle.
摘要
2019 年冠状病毒病（COVID-19）大流行突显了缺乏针对急性病毒病的批准药物。植物被认为是治疗多种疾病和临床病症的药物的不竭来源，但植物衍生化合物在抗病毒领域几乎没有成功。在这里，我们提出了使用包括生物碱、类黄酮、多酚和单宁在内的维管植物化合物作为抗病毒药物的案例，特别是用于治疗 COVID-19。我们回顾了这些植物化学物质对抗 SARS-CoV-2 感染的使用的现有证据，并介绍了它们在 SARS-CoV-2 复制周期中的潜在靶标。
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