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本文引用的文献

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Low dose of emetine as potential anti-SARS-CoV-2 virus therapy: preclinical in vitro inhibition and in vivo pharmacokinetic evidences.低剂量吐根碱作为潜在的抗SARS-CoV-2病毒疗法：临床前体外抑制和体内药代动力学证据
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Resveratrol and Pterostilbene Inhibit SARS-CoV-2 Replication in Air-Liquid Interface Cultured Human Primary Bronchial Epithelial Cells.白藜芦醇和紫檀芪抑制气液界面培养的人原代支气管上皮细胞中的 SARS-CoV-2 复制。
Viruses. 2021 Jul 10;13(7):1335. doi: 10.3390/v13071335.
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Biochemical characterization of protease activity of Nsp3 from SARS-CoV-2 and its inhibition by nanobodies.SARS-CoV-2 Nsp3 蛋白酶活性的生化特性及其纳米抗体抑制作用。
PLoS One. 2021 Jul 16;16(7):e0253364. doi: 10.1371/journal.pone.0253364. eCollection 2021.
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Clinical efficacy of low-dose emetine for patients with COVID-19: a real-world study.低剂量依米丁治疗新型冠状病毒肺炎患者的临床疗效：一项真实世界研究
J BioX Res. 2021 Jun;4(2):53-59. doi: 10.1097/JBR.0000000000000076. Epub 2020 Dec 3.
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Significant Inactivation of SARS-CoV-2 In Vitro by a Green Tea Catechin, a Catechin-Derivative, and Black Tea Galloylated Theaflavins.绿茶儿茶素、儿茶素衍生物和红茶没食子酰化茶黄素体外有效灭活 SARS-CoV-2。
Molecules. 2021 Jun 11;26(12):3572. doi: 10.3390/molecules26123572.
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Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp3 papain-like protease.通过筛选 Nsp3 木瓜蛋白酶样蛋白酶的小分子抑制剂来鉴定 SARS-CoV-2 抗病毒化合物。
Biochem J. 2021 Jul 16;478(13):2517-2531. doi: 10.1042/BCJ20210244.
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Phenolic compounds disrupt spike-mediated receptor-binding and entry of SARS-CoV-2 pseudo-virions.酚类化合物可破坏刺突介导的严重急性呼吸综合征冠状病毒2（SARS-CoV-2）假病毒颗粒的受体结合及进入过程。
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Oral Curcumin With Piperine as Adjuvant Therapy for the Treatment of COVID-19: A Randomized Clinical Trial.口服姜黄素与胡椒碱作为辅助治疗新冠病毒病的随机临床试验
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SARS-CoV-2 envelope protein causes acute respiratory distress syndrome (ARDS)-like pathological damages and constitutes an antiviral target.SARS-CoV-2 包膜蛋白导致急性呼吸窘迫综合征（ARDS）样病理损伤，是抗病毒的靶点。
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Identification of SARS-CoV-2 Receptor Binding Inhibitors by In Vitro Screening of Drug Libraries.通过药物文库的体外筛选鉴定 SARS-CoV-2 受体结合抑制剂。
Molecules. 2021 May 27;26(11):3213. doi: 10.3390/molecules26113213.

用于治疗 COVID-19 的植物化学物质。

Phytochemicals for the treatment of COVID-19.

机构信息

Department of Pharmacy, Korea University College of Pharmacy, Sejong, 30019, Republic of Korea.

出版信息

J Microbiol. 2021 Nov;59(11):959-977. doi: 10.1007/s12275-021-1467-z. Epub 2021 Nov 1.

DOI:10.1007/s12275-021-1467-z
PMID:34724178
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8559138/
Abstract

The coronavirus disease 2019 (COVID-19) pandemic has underscored the lack of approved drugs against acute viral diseases. Plants are considered inexhaustible sources of drugs for several diseases and clinical conditions, but plant-derived compounds have seen little success in the field of antivirals. Here, we present the case for the use of compounds from vascular plants, including alkaloids, flavonoids, polyphenols, and tannins, as antivirals, particularly for the treatment of COVID-19. We review current evidence for the use of these phytochemicals against SARS-CoV-2 infection and present their potential targets in the SARS-CoV-2 replication cycle.

摘要

2019 年冠状病毒病（COVID-19）大流行突显了缺乏针对急性病毒病的批准药物。植物被认为是治疗多种疾病和临床病症的药物的不竭来源，但植物衍生化合物在抗病毒领域几乎没有成功。在这里，我们提出了使用包括生物碱、类黄酮、多酚和单宁在内的维管植物化合物作为抗病毒药物的案例，特别是用于治疗 COVID-19。我们回顾了这些植物化学物质对抗 SARS-CoV-2 感染的使用的现有证据，并介绍了它们在 SARS-CoV-2 复制周期中的潜在靶标。