Rosenquist J B, Nystrom E
Anesth Prog. 1987 Jan-Feb;34(1):6-9.
In a double-blind crossover study, the effect on postoperative pain of lidocaine plus diflunisal was compared with that of bupivacaine and placebo. Forty-eight patients with bilateral impactions of lower third molars had these removed on two occasions four weeks apart. One pain-control regimen was used on one occasion and the alternate on the second. The pain intensity was indicated on a visual analog scale at 2, 3, 4, 5, and 6 hours postoperatively. The pain values for the first postoperative hours were higher for the lidocaine diflunisal combination, whereas after 5 hours the opposite was true. Significantly more patients preferred the combination of lidocaine and diflunisal. Three patients reported fatigue postoperatively during the day of surgery, which they attributed to the operation and not to the analgesics used.
在一项双盲交叉研究中,将利多卡因加双氟尼酸对术后疼痛的影响与布比卡因和安慰剂进行了比较。48例双侧下颌第三磨牙阻生患者分两次拔除,两次间隔四周。一次使用一种疼痛控制方案,另一次使用另一种。术后2、3、4、5和6小时通过视觉模拟量表指示疼痛强度。术后最初几个小时,利多卡因与双氟尼酸联合使用时疼痛值较高,而5小时后情况相反。明显更多患者更喜欢利多卡因和双氟尼酸的组合。3例患者在手术当天术后报告疲劳,他们将其归因于手术而非所用的镇痛药。