Najafimehr Hadis, Aghdaei Hamid Asadzadeh, Pourhoseingholi Mohamad Amin, Shalmani Hamid Mohaghegh, Vahedian-Azimi Amir, Kroh Matthew, Zali Mohammad Reza, Sahebkar Amirhossein
Basic and Molecular Epidemiology of Gastrointestinal Disorders Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Gastroenterol Res Pract. 2021 Oct 23;2021:4874459. doi: 10.1155/2021/4874459. eCollection 2021.
Colorectal cancer (CRC) and inflammatory bowel disease (IBD) are closely interrelated. However, the effect of having a family history of one disease on the risk of another remains undetermined.
The purpose of this meta-analysis was to estimate the prevalence of a family history of CRC among patients with IBD, as well as the prevalence of a family history of IBD among patients with CRC.
PubMed, Scopus, Embase, Web of Science, and Google Scholar were searched to identify studies reporting the prevalence of family history of IBD among patients with CRC, in addition to the prevalence of family history of CRC among IBD patients. Criteria for study inclusion consisted of the following: (1) studies that evaluated either IBD or CRC and dysplasia, (2) included all age groups, and (3) evaluated the family history effects for IBD or CRC. The total number of IBD patients and IBD patients with a family history of CRC and the total number of CRC patients and CRC patients with a family history of IBD were reviewed. The pooled prevalence of diseases was also estimated according to degree of relatives and geographical area. Random-effects models were used for estimating pooled prevalence.
A total of 27 studies were included with 26,576 IBD and 9,181 CRC or dysplasia patients. Eligible studies included 13 case-control, 10 cohort, and 4 cross-sectional types. The pooled prevalence of a family history of CRC among patients with IBD was 6% (95% CI: 4-9%). The pooled prevalence for first- and second-degree relatives (11%, 95% CI: 0-37%) was more than that for the other relative subgroups of relatedness degree. The prevalence in the American regions (8% (95% CI: 5-13%)) was higher than that in the others. The pooled prevalence for a family history of IBD among CRC or dysplasia patients was 11% (95% CI: 6-16%). The pooled prevalence for first-degree relatives (13% (95% CI: 3-28%) was higher than that for the other relative subgroups of relatedness degree; it was also greater in American countries (15%, 95% CI: 8-23%).
This study emphasizes the relationship between a family history of IBD and CRC development. Additionally, there was notable prevalence for a family history of CRC among IBD patients. American countries and first-degree relatives were identified to have a higher prevalence for both disease processes.
结直肠癌（CRC）与炎症性肠病（IBD）密切相关。然而，一种疾病的家族史对另一种疾病风险的影响仍未确定。
本荟萃分析的目的是估计IBD患者中CRC家族史的患病率，以及CRC患者中IBD家族史的患病率。
检索了PubMed、Scopus、Embase、Web of Science和谷歌学术，以识别报告CRC患者中IBD家族史患病率以及IBD患者中CRC家族史患病率的研究。纳入研究的标准如下：（1）评估IBD或CRC及发育异常的研究；（2）纳入所有年龄组；（3）评估IBD或CRC的家族史影响。回顾了IBD患者总数、有CRC家族史的IBD患者总数、CRC患者总数以及有IBD家族史的CRC患者总数。还根据亲属程度和地理区域估计了疾病的合并患病率。采用随机效应模型估计合并患病率。
共纳入27项研究，涉及26576例IBD患者和9181例CRC或发育异常患者。符合条件的研究包括13项病例对照研究、10项队列研究和4项横断面研究。IBD患者中CRC家族史的合并患病率为6%（95%CI：4-9%）。一级和二级亲属的合并患病率（11%，95%CI：0-37%）高于其他亲属关系程度亚组。美国地区的患病率（8%（95%CI：5-13%））高于其他地区。CRC或发育异常患者中IBD家族史的合并患病率为11%（95%CI：6-16%）。一级亲属的合并患病率（13%（95%CI：3-28%））高于其他亲属关系程度亚组；在美国国家中也更高（15%，95%CI：8-23%）。
本研究强调了IBD家族史与CRC发生之间的关系。此外，IBD患者中CRC家族史的患病率显著。美国国家和一级亲属在这两种疾病过程中的患病率较高。
