Department of Biochemistry, Government College University, Faisalabad-, Pakistan.
Department of Nutritional Sciences, Government College University, Faisalabad-, Pakistan.
Biomed Res Int. 2021 Oct 23;2021:3094571. doi: 10.1155/2021/3094571. eCollection 2021.
Obesity is a chronic metabolic and noncommunicable disease that affects 50% of world population. Reactive oxygen species and oxidative stress are interconnected with the obesity and several metabolic disorders, gaining the attention of scientific community to combat this problem naturally. Among various fruits, mango as a yellow fruit is rich in polyphenols, carotenoids, terpenes, and flavonoids that act as antioxidants to protect against free radicals produced in the body. The present study was performed to explore antioxidant potential of mango peels against dyslipidemia and oxidative stress in overweight subjects. The female volunteers ( = 31) between 25 and 45 years of age having a body mass index (BMI) of 25.0-29.9 (overweight) were included in this study, while participants with complications as diabetes, hypertension, cardiovascular, and liver diseases were excluded. The treatment group consumed 1 g mango peel powder for 84 days. The subjects were analyzed for biochemical analysis, antioxidant status, and anthropometric measurements at baseline and end of the study period. Further, at the end of study, the safety evaluation tests were also performed. The results showed that upon consumption of mango peel powder, low-density lipoproteins (LDL), cholesterol, triglyceride, urea, and creatinine levels were decreased and high-density lipoprotein (HDL) level was increased ( ≤ 0.05), while thiobarbituric acid reactive substances (TBARS) showed increased antioxidant status ( ≤ 0.05) which suggests that mango peels have a strong management potential against oxidative stress and dyslipidemia in obese subjects.
肥胖是一种慢性代谢和非传染性疾病，影响着全球 50%的人口。活性氧和氧化应激与肥胖和几种代谢紊乱相互关联，引起了科学界的关注，以自然方式对抗这一问题。在各种水果中，芒果作为一种黄色水果，富含多酚、类胡萝卜素、萜烯和类黄酮，这些物质具有抗氧化作用，可以保护身体免受自由基的伤害。本研究旨在探索芒果皮的抗氧化潜力，以对抗超重人群的血脂异常和氧化应激。这项研究纳入了年龄在 25 至 45 岁之间、BMI 为 25.0-29.9 的女性志愿者（n=31），排除了患有糖尿病、高血压、心血管和肝脏疾病等并发症的参与者。治疗组连续 84 天每天摄入 1 克芒果皮粉。在研究开始和结束时，对受试者进行生化分析、抗氧化状态和人体测量学指标的分析。此外，在研究结束时，还进行了安全性评估测试。结果表明，食用芒果皮粉后，低密度脂蛋白（LDL）、胆固醇、甘油三酯、尿素和肌酐水平降低，高密度脂蛋白（HDL）水平升高（≤0.05），而硫代巴比妥酸反应物质（TBARS）的抗氧化状态增强（≤0.05），这表明芒果皮对肥胖人群的氧化应激和血脂异常具有很强的管理潜力。
