Division of Acute Care Surgery, Department of Surgery, 588543Johns Hopkins University School of Medicine, Baltimore, MD, USA.
The Department of Surgery, 1466The Johns Hopkins Bayview Medical Center, Baltimore, MD, USA.
Am Surg. 2021 Nov;87(11):1760-1765. doi: 10.1177/00031348211054072. Epub 2021 Nov 2.
The interaction of increasing age, Injury Severity Score (ISS), and complications is not well described in geriatric trauma patients. We hypothesized that failure to rescue rate from any complication worsens with age and injury severity.
The National Trauma Data Bank (NTDB) was queried for injured patients aged 65 years or older from January 1, 2013 through December 31, 2016. Demographics and injury characteristics were used to compare groups. Mortality rates were calculated across subgroups of age and ISS, and captured with heatmaps. Multivariable logistic regression was performed to identify independent predictors of mortality.
614,496 geriatric trauma patients were included; 151,880 (24.7%) experienced a complication. Those with complications tended to be older, female, non-white, have non-blunt mechanism, higher ISS, and hypotension on arrival. Overall mortality was highest (19%) in the oldest (≥86 years old) and most severely injured (ISS ≥ 25) patients, with constant age increasing across each ISS group was associated with a 157% increase in overall mortality ( < .001, 95% CI: 148-167%). Holding ISS stable, increasing age group was associated with a 48% increase in overall mortality ( < .001, 95% CI: 44-52%). After controlling for standard demographic variables at presentation, the existence of any complication was an independent predictor of overall mortality in geriatric patients (OR: 2.3; 95% CI: 2.2-2.4).
Any complication was an independent risk factor for mortality, and scaled with increasing age and ISS in geriatric patients. Differences in failure to rescue between populations may reflect critical differences in physiologic vulnerability that could represent targets for interventions.
在老年创伤患者中,年龄、损伤严重程度评分(ISS)和并发症之间的相互作用尚未得到很好的描述。我们假设,任何并发症的抢救失败率都会随着年龄和损伤严重程度的增加而恶化。
从 2013 年 1 月 1 日至 2016 年 12 月 31 日,从国家创伤数据库(NTDB)中查询年龄在 65 岁或以上的受伤患者。使用人口统计学和损伤特征来比较各组。根据年龄和 ISS 的亚组计算死亡率,并通过热图进行捕获。进行多变量逻辑回归以确定死亡率的独立预测因素。
共纳入 614496 例老年创伤患者;151880 例(24.7%)发生并发症。有并发症的患者年龄较大、女性、非白人、非钝性机制、ISS 较高,入院时伴有低血压。年龄最大(≥86 岁)和损伤最严重(ISS≥25)的患者总体死亡率最高(19%),随着每个 ISS 组年龄的增加,总体死亡率增加了 157%(<0.001,95%CI:148-167%)。在保持 ISS 稳定的情况下,年龄组增加与总体死亡率增加 48%相关(<0.001,95%CI:44-52%)。在呈现时控制标准人口统计学变量后,任何并发症的存在都是老年患者总体死亡率的独立预测因素(OR:2.3;95%CI:2.2-2.4)。
任何并发症都是老年患者死亡的独立危险因素,且与 ISS 和年龄的增加成正比。人群之间抢救失败的差异可能反映了生理脆弱性的关键差异,这些差异可能代表干预的目标。