Marijan Kovačić, Obala kneza Branimira 2e, 23000 Zadar, Croatia,
Croat Med J. 2021 Oct 31;62(5):518-522. doi: 10.3325/cmj.2021.62.518.
Celiac disease is the most common chronic gastroenterological disease. One of the extraintestinal manifestations of this multifaceted disease are changes in the oral mucosa. However, ulceration leading to the destruction of the soft and hard tissues of the orofacial region has not been reported so far. We report on the development of necrotizing ulcerative stomatitis in a 41-year-old woman with celiac disease. The initial ulcerative lesion was located in the lower lip mucosa. Necrosis of all layers of the left side of the lip and oral commissure progressed very quickly. The resulting defect required plastic reconstructive surgery. We successfully compensated for the defect by applying a combination of two flaps from the remaining tissue of the lower lip. Oral competence was established immediately after the operation, and a very good esthetic appearance two months later.
乳糜泻是最常见的慢性胃肠疾病。这种多方面疾病的一种肠外表现是口腔黏膜的变化。然而，迄今为止，尚未有报道称这种疾病会导致口腔颌面部软硬组织的溃疡破坏。我们报告了一例 41 岁女性乳糜泻患者发生坏死性溃疡性口炎。最初的溃疡性病变位于下唇黏膜。左侧唇和口角的所有层很快发生坏死。由此产生的缺损需要整形修复手术。我们通过应用下唇剩余组织的两个皮瓣成功地补偿了缺损。手术后立即恢复了口腔功能，两个月后外观非常美观。
