Joint School of National University of Singapore and Tianjin University, International Campus of Tianjin University, Fuzhou 350207, China.
Tianjin Key Laboratory of Molecular Optoelectronic Sciences, Department of Chemistry, School of Science, Tianjin University, Tianjin 300072, China.
J Am Chem Soc. 2021 Nov 24;143(46):19243-19256. doi: 10.1021/jacs.1c07678. Epub 2021 Nov 3.
Organic cocrystal engineering refers to two or more organic molecules stoichiometrically combined and held together by noncovalent intermolecular interactions, which differs from standard chemical synthesis involving covalent bond breakage and formation. Organic cocrystals have unique properties and offer a new strategy for creating enhanced organics. First, however, some key questions need to be addressed: How do diverse monomers affect the intermolecular interaction kinetics during cocrystallization? How do the intermolecular forces in cocrystals affect cocrystal functions? In this Perspective, the definition and advantages of organic cocrystal engineering, specifically in the construction of a reliable intermolecular interaction-stacking structure-performance relationship, are outlined. Additionally, recent developments in the field and the questions above are discussed. Finally, a brief conclusion and some hints on likely future developments are provided.
有机共晶工程是指两个或更多的有机分子以化学计量比结合在一起，并通过非共价分子间相互作用保持在一起，这与涉及共价键断裂和形成的标准化学合成不同。有机共晶具有独特的性质，并为创造增强型有机材料提供了一种新策略。然而，首先需要解决一些关键问题：不同的单体如何影响共晶化过程中的分子间相互作用动力学？共晶中的分子间力如何影响共晶功能？在本观点中，概述了有机共晶工程的定义和优势，特别是在构建可靠的分子间相互作用-堆积结构-性能关系方面。此外，还讨论了该领域的最新发展和上述问题。最后，提供了一个简短的结论和对未来可能发展的一些提示。
