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鉴定与阿尔茨海默病和重度抑郁症相关的枢纽基因。

Identification of Hub Genes Related to Alzheimer's Disease and Major Depressive Disorder.

机构信息

Department of Neurology, General Hospital, 117865Tianjin Medical University, Tianjin, China.

Department of Genetics, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.

出版信息

Am J Alzheimers Dis Other Demen. 2021 Jan-Dec;36:15333175211046123. doi: 10.1177/15333175211046123.

DOI:10.1177/15333175211046123
PMID:34732058
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10695082/
Abstract

BackgroundAlthough many studies reported a close relationship between depression and Alzheimer's disease (AD), the underlying pathophysiological mechanism remains unclear. The present study aimed to investigate the mechanism of AD and major depressive disorder (MDD). The datasets were downloaded from the Gene Expression Omnibus. After screening differentially expressed genes (DEGs), gene ontology and pathway analysis were performed and protein-protein interaction, TF-target gene, and miRNA-target gene networks were established. 171 DEGs of AD-related datasets and 79 DEGs shared by AD and MDD were detected. Functional analysis revealed that AD and MDD common genes were significantly enriched in circadian entrainment and long-term depression signaling pathways. Five hub genes were identified after construction of networks and validation of hub gene signatures. In conclusion, DYNC1H1, MAPRE3, TTBK2, ITGB1, and WASL may be potential targets for the diagnosis and treatment of AD and MDD.

摘要

背景

尽管许多研究报告称抑郁症与阿尔茨海默病（AD）之间存在密切关系，但潜在的病理生理机制仍不清楚。本研究旨在探讨 AD 和重度抑郁症（MDD）的发病机制。从基因表达综合数据库中下载数据集。筛选差异表达基因（DEGs）后，进行基因本体论和通路分析，并建立蛋白质-蛋白质相互作用、TF-靶基因和 miRNA-靶基因网络。检测到 171 个与 AD 相关数据集的 DEGs 和 79 个 AD 和 MDD 共有的 DEGs。功能分析表明，AD 和 MDD 共有基因在昼夜节律调节和长期抑郁信号通路中显著富集。构建网络并验证枢纽基因特征后，确定了 5 个枢纽基因。总之，DYNC1H1、MAPRE3、TTBK2、ITGB1 和 WASL 可能是 AD 和 MDD 诊断和治疗的潜在靶点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1232/10695082/ecff3a1383ab/10.1177_15333175211046123-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1232/10695082/1f45356560e9/10.1177_15333175211046123-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1232/10695082/18cec086aec0/10.1177_15333175211046123-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1232/10695082/0fffb8717f69/10.1177_15333175211046123-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1232/10695082/d93e221481b0/10.1177_15333175211046123-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1232/10695082/ecff3a1383ab/10.1177_15333175211046123-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1232/10695082/1f45356560e9/10.1177_15333175211046123-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1232/10695082/18cec086aec0/10.1177_15333175211046123-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1232/10695082/0fffb8717f69/10.1177_15333175211046123-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1232/10695082/d93e221481b0/10.1177_15333175211046123-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1232/10695082/ecff3a1383ab/10.1177_15333175211046123-fig5.jpg

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