Department of Traditional Chinese Gynecology, Changhai Hospital Affiliated with Naval Medical University, Shanghai, China.
The Chinese People's Liberation Army 91666 troops, Zhoushan, China.
Reprod Health. 2021 Nov 3;18(1):217. doi: 10.1186/s12978-021-01250-4.
Many studies have considered maternal age as a determinant factor for success in assisted reproductive technologies (ART), but the potential role of paternal age on neonatal outcomes has been overlooked. This study aimed to explore the association between paternal age and birthweight in frozen embryo transfer (FET) cycles.
This retrospective study involved singleton live births born to women undergoing frozen embryo transfer from January 2013 to December 2017 at a tertiary care center in Shanghai, China. The paternal age was classified into four categories: ≤ 30, 31-35, 36-40, and ≥ 41 years. The group consisting of respondents with paternal age of 31-35 was set as the reference group. Singleton birthweight was the primary outcome measure. Z-scores were calculated according to gestational age and newborn gender on birthweight based on the national birthweight reference. Multivariable linear regression analysis was performed to reveal the relationship between paternal age and newborns' birthweight after considering several potential confounders.
Exactly 9765 women who fulfilled the inclusion criteria were enrolled. No significant difference was found on mean birthweight (P = 0.082) and gestation-adjusted Z-scores (P = 0.569) among paternal age categories. The reference group and the group with aged 36-40 years had the highest mean birthweight and Z-scores, respectively (3350.2 ± 467.8 g, 0.36 ± 1.00). A decline in mean birthweight with paternal age was observed, and the group over 40 years had the lowest value of 3309.4 ± 474.3 g, but the difference was not statistically significant. In multivariate analyses, the adjusted odds of very low birthweight (LBW), LBW, and high birthweight in the reference group did not significantly differ with the three other groups. After correcting several potential confounders, no significant correlation was observed between paternal age and neonatal birthweight (P = 0.289).
Paternal age was not associated with mean birthweight and gestational age- and gender-adjusted birthweight (Z-scores) of singletons among women who became pregnant in FET cycles.
许多研究已经将母亲年龄视为辅助生殖技术（ART）成功的决定因素，但父亲年龄对新生儿结局的潜在作用被忽视了。本研究旨在探讨冻融胚胎移植（FET）周期中父亲年龄与出生体重之间的关系。
这是一项回顾性研究，纳入了 2013 年 1 月至 2017 年 12 月在中国上海一家三级保健中心接受冻融胚胎移植的单胎活产。父亲年龄分为四组：≤30 岁、31-35 岁、36-40 岁和≥41 岁。将父亲年龄为 31-35 岁的组设为参照组。单胎出生体重为主要结局指标。根据出生体重的胎龄和新生儿性别，基于国家出生体重参考值计算 Z 分数。在考虑了几个潜在的混杂因素后，采用多变量线性回归分析来揭示父亲年龄与新生儿出生体重之间的关系。
共有 9765 名符合纳入标准的女性被纳入研究。在父亲年龄组中，出生体重的均值（P=0.082）和胎龄校正 Z 分数（P=0.569）均无显著差异。参照组和 36-40 岁组的平均出生体重和 Z 分数最高（分别为 3350.2±467.8 g 和 0.36±1.00）。随着父亲年龄的增加，出生体重呈下降趋势，40 岁以上组的出生体重最低，为 3309.4±474.3 g，但差异无统计学意义。多变量分析显示，参照组与其他三组比较，极低出生体重（LBW）、低出生体重（LBW）和高出生体重的调整后比值比差异无统计学意义。在校正了几个潜在混杂因素后，父亲年龄与新生儿出生体重之间无显著相关性（P=0.289）。
在接受 FET 周期妊娠的女性中，父亲年龄与单胎的平均出生体重和胎龄及性别校正后的出生体重（Z 分数）无关。
