Munchel Ashley, Chen Allen, Symons Heather
Pediatric Hematology/Oncology, The Johns Hopkins Hospital, Baltimore, MD ; Pediatric Oncology Branch at the National Institutes of Health, Bethesda, MD.
Division of Oncology, Sidney Kimmel Comprehensive Cancer Center at The Johns Hopkins Hospital, Baltimore, MD ; Division of Pediatrics, Sidney Kimmel Comprehensive Cancer Center at The Johns Hopkins Hospital, Baltimore, MD.
Clin Pediatr Emerg Med. 2011 Sep;12(3):233-244. doi: 10.1016/j.cpem.2011.07.005.
Hematopoietic cell transplantation is the only potentially curative option for a variety of pediatric malignant and nonmalignant disorders. Despite advances in transplantation biology and immunology as well as in posttransplant management that have contributed to improved survival and decreased transplant-related mortality, hematopoietic cell transplantation does not come without significant risk of complications. When patients who have undergone hematopoietic cell transplantation present to the emergency department, it is important to consider a variety of therapy-related complications to optimize management and outcome. In this article, we use clinical cases to highlight some of the more common emergent complications after hematopoietic cell transplantation.
造血细胞移植是治疗多种儿童恶性和非恶性疾病唯一具有潜在治愈可能的选择。尽管移植生物学、免疫学以及移植后管理方面取得了进展，这些进展有助于提高生存率并降低移植相关死亡率，但造血细胞移植并非没有显著的并发症风险。当接受过造血细胞移植的患者前往急诊科就诊时，考虑各种与治疗相关的并发症对于优化管理和改善预后很重要。在本文中，我们通过临床病例来突出造血细胞移植后一些较常见的紧急并发症。
