• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

CX3C-趋化因子受体 1 调节睡眠剥夺引起的认知功能障碍。

CX3C-chemokine receptor 1 modulates cognitive dysfunction induced by sleep deprivation.

机构信息

Department of Neurology, Fujian Institute of Geriatrics, Fujian Medical University Union Hospital, Fuzhou, Fujian 350001, China.

Fujian Key Laboratory of Molecular Neurology, Fujian Medical University, Fuzhou, Fujian 350001, China.

出版信息

Chin Med J (Engl). 2021 Nov 3;135(2):205-215. doi: 10.1097/CM9.0000000000001769.

DOI:10.1097/CM9.0000000000001769
PMID:34732662
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8769116/
Abstract

BACKGROUND

Microglia plays an indispensable role in the pathological process of sleep deprivation (SD). Here, the potential role of microglial CX3C-chemokine receptor 1 (CX3CR1) in modulating the cognition decline during SD was evaluated in terms of microglial neuroinflammation and synaptic pruning. In this study, we aimed to investigat whether the interference in the microglial function by the CX3CR1 knockout affects the CNS's response to SD.

METHODS

Middle-aged wild-type (WT) C57BL/6 and CX3CR1-/- mice were either subjected to SD or allowed normal sleep (S) for 8 h to mimic the pathophysiological changes of middle-aged people after staying up all night. After which, behavioral and histological tests were used to explore their different changes.

RESULTS

CX3CR1 deficiency prevented SD-induced cognitive impairments, unlike WT groups. Compared with the CX3CR1-/- S group, the CX3CR1-/- SD mice reported a markedly decreased microglia and cellular oncogene fos density in the dentate gyrus (DG), decreased expression of pro-inflammatory cytokines, and decreased microglial phagocytosis-related factors, whereas increased levels of anti-inflammatory cytokines in the hippocampus and a significant increase in the density of spines of the DG were also noted.

CONCLUSIONS

These findings suggest that CX3CR1 deficiency leads to different cerebral behaviors and responses to SD. The inflammation-attenuating activity and the related modification of synaptic pruning are possible mechanism candidates, which indicate CX3CR1 as a candidate therapeutic target for the prevention of the sleep loss-induced cognitive impairments.

摘要

背景

小胶质细胞在睡眠剥夺（SD）的病理过程中起着不可或缺的作用。在这里，我们评估了小胶质细胞 CX3C-趋化因子受体 1（CX3CR1）在调节 SD 期间认知能力下降中的潜在作用，特别是在小胶质细胞神经炎症和突触修剪方面。在这项研究中，我们旨在研究 CX3CR1 缺失对小胶质细胞功能的干扰是否会影响中枢神经系统对 SD 的反应。

方法

中年野生型（WT）C57BL/6 和 CX3CR1-/- 小鼠要么接受 SD，要么允许正常睡眠（S）8 小时，以模拟通宵熬夜后中老年人的病理生理变化。之后，使用行为和组织学测试来探索它们的不同变化。

结果

与 WT 组不同，CX3CR1 缺失可预防 SD 引起的认知障碍。与 CX3CR1-/- S 组相比，CX3CR1-/- SD 小鼠在齿状回（DG）中的小胶质细胞和细胞原癌基因 fos 密度明显降低，促炎细胞因子表达降低，小胶质细胞吞噬相关因子减少，而海马中的抗炎细胞因子水平升高，DG 中的棘密度显著增加。

结论

这些发现表明，CX3CR1 缺失导致大脑行为和对 SD 的反应不同。炎症减弱活性和相关的突触修剪修饰可能是候选机制，这表明 CX3CR1 是预防睡眠剥夺引起的认知障碍的候选治疗靶点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5dde/8769116/b7239bfd92b2/cm9-135-205-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5dde/8769116/e77075c74cf0/cm9-135-205-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5dde/8769116/f1e4fab60e78/cm9-135-205-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5dde/8769116/1e1f8c9ac487/cm9-135-205-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5dde/8769116/acfa64f4e342/cm9-135-205-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5dde/8769116/aa4d29de4b81/cm9-135-205-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5dde/8769116/b7239bfd92b2/cm9-135-205-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5dde/8769116/e77075c74cf0/cm9-135-205-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5dde/8769116/f1e4fab60e78/cm9-135-205-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5dde/8769116/1e1f8c9ac487/cm9-135-205-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5dde/8769116/acfa64f4e342/cm9-135-205-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5dde/8769116/aa4d29de4b81/cm9-135-205-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5dde/8769116/b7239bfd92b2/cm9-135-205-g006.jpg

相似文献

1
CX3C-chemokine receptor 1 modulates cognitive dysfunction induced by sleep deprivation.CX3C-趋化因子受体 1 调节睡眠剥夺引起的认知功能障碍。
Chin Med J (Engl). 2021 Nov 3;135(2):205-215. doi: 10.1097/CM9.0000000000001769.
2
Dysfunctional synaptic pruning by microglia correlates with cognitive impairment in sleep-deprived mice: Involvement of CX3CR1 signaling.小胶质细胞功能失调的突触修剪与睡眠剥夺小鼠的认知障碍相关：CX3CR1信号通路的参与。
Neurobiol Stress. 2023 Jun 25;25:100553. doi: 10.1016/j.ynstr.2023.100553. eCollection 2023 Jul.
3
Involvement of CX3CL1/CX3CR1 in depression and cognitive impairment induced by chronic unpredictable stress and relevant underlying mechanism.慢性不可预测应激诱导抑郁和认知障碍及其相关机制中 CX3CL1/CX3CR1 的作用。
Behav Brain Res. 2020 Mar 2;381:112371. doi: 10.1016/j.bbr.2019.112371. Epub 2019 Nov 22.
4
Microglia-mediated synaptic pruning is impaired in sleep-deprived adolescent mice.睡眠剥夺的青春期小鼠中，小胶质细胞介导的突触修剪受损。
Neurobiol Dis. 2019 Oct;130:104517. doi: 10.1016/j.nbd.2019.104517. Epub 2019 Jun 21.
5
Lipopolysaccharide-induced maternal immune activation modulates microglial CX3CR1 protein expression and morphological phenotype in the hippocampus and dentate gyrus, resulting in cognitive inflexibility during late adolescence.脂多糖诱导的母体免疫激活调节海马体和齿状回小胶质细胞 CX3CR1 蛋白表达和形态表型，导致青春期后期认知灵活性降低。
Brain Behav Immun. 2021 Oct;97:440-454. doi: 10.1016/j.bbi.2021.07.025. Epub 2021 Jul 31.
6
Microglia contribute to social behavioral adaptation to chronic stress.小胶质细胞有助于对慢性应激的社会行为适应。
Glia. 2021 Oct;69(10):2459-2473. doi: 10.1002/glia.24053. Epub 2021 Jun 19.
7
Absence of microglial CX3CR1 impairs the synaptic integration of adult-born hippocampal granule neurons.小胶质细胞 CX3CR1 的缺失会损害成年海马颗粒神经元的突触整合。
Brain Behav Immun. 2018 Feb;68:76-89. doi: 10.1016/j.bbi.2017.10.002. Epub 2017 Oct 7.
8
CX3CR1 deficiency aggravates amyloid driven neuronal pathology and cognitive decline in Alzheimer's disease.CX3CR1 缺失加重阿尔茨海默病中淀粉样驱动的神经元病变和认知衰退。
Mol Neurodegener. 2022 Jun 28;17(1):47. doi: 10.1186/s13024-022-00545-9.
9
Fractalkine receptor (CX3CR1) deficiency sensitizes mice to the behavioral changes induced by lipopolysaccharide. fractalkine 受体（CX3CR1）缺陷使小鼠对脂多糖诱导的行为变化敏感。
J Neuroinflammation. 2010 Dec 17;7:93. doi: 10.1186/1742-2094-7-93.
10
Increased neuroplasticity and hippocampal microglia activation in a mice model of rapid antidepressant treatment.快速抗抑郁治疗小鼠模型中神经可塑性增加及海马小胶质细胞激活
Behav Brain Res. 2016 Sep 15;311:392-402. doi: 10.1016/j.bbr.2016.05.063. Epub 2016 Jun 2.

引用本文的文献

1
Development and validation of an explainable machine learning model for predicting the risk of sleep disorders in older adults with multimorbidity: a cross-sectional study.一种用于预测患有多种疾病的老年人睡眠障碍风险的可解释机器学习模型的开发与验证：一项横断面研究。
Front Public Health. 2025 Aug 11;13:1619406. doi: 10.3389/fpubh.2025.1619406. eCollection 2025.
2
Sleep deprivation and dendritic architecture: a systematic review and meta-analysis.睡眠剥夺与树突结构：一项系统综述和荟萃分析
Sleep. 2025 Sep 9;48(9). doi: 10.1093/sleep/zsaf146.
3
Neuroinflammatory Loop in Schizophrenia, Is There a Relationship with Symptoms or Cognition Decline?

本文引用的文献

1
Rapid eye movement sleep deprivation impairs neuronal plasticity and reduces hippocampal neuronal arborization in male albino rats: Noradrenaline is involved in the process.快速眼动睡眠剥夺损害雄性白化大鼠神经元可塑性并减少海马神经元树突分支：去甲肾上腺素参与了这一过程。
J Neurosci Res. 2021 Jul;99(7):1815-1834. doi: 10.1002/jnr.24838. Epub 2021 Apr 5.
2
Sleep-related symptoms in multiple system atrophy: determinants and impact on disease severity.多系统萎缩中与睡眠相关的症状：决定因素及其对疾病严重程度的影响。
Chin Med J (Engl). 2020 Nov 23;134(6):690-698. doi: 10.1097/CM9.0000000000001211.
3
Activation of MORs in the VTA induces changes on cFos expression in different projecting regions: Effect of inflammatory pain.
精神分裂症中的神经炎症循环，与症状或认知衰退有关系吗？
Int J Mol Sci. 2025 Jan 1;26(1):310. doi: 10.3390/ijms26010310.
4
Physical activity, sleep disorders, and type of work in the prevention of cognitive function decline in patients with hypertension.体力活动、睡眠障碍和工作类型在预防高血压患者认知功能下降中的作用。
BMC Public Health. 2023 Dec 6;23(1):2431. doi: 10.1186/s12889-023-17343-7.
5
CX3CL1/CX3CR1 signal mediates M1-type microglia and accelerates high-altitude-induced forgetting.CX3CL1/CX3CR1信号介导M1型小胶质细胞并加速高原诱导的遗忘。
Front Cell Neurosci. 2023 May 10;17:1189348. doi: 10.3389/fncel.2023.1189348. eCollection 2023.
6
Possible Neuropathology of Sleep Disturbance Linking to Alzheimer's Disease: Astrocytic and Microglial Roles.与阿尔茨海默病相关的睡眠障碍的可能神经病理学：星形胶质细胞和小胶质细胞的作用。
Front Cell Neurosci. 2022 Jun 9;16:875138. doi: 10.3389/fncel.2022.875138. eCollection 2022.
VTA 中 MORs 的激活诱导不同投射区域中 cFos 表达的变化：炎性疼痛的影响。
Neurochem Int. 2019 Dec;131:104521. doi: 10.1016/j.neuint.2019.104521. Epub 2019 Aug 13.
4
Maintenance of Fluorescence During Paraffin Embedding of Fluorescent Protein-Labeled Specimens.荧光蛋白标记标本石蜡包埋过程中荧光的维持
Front Neurosci. 2019 Jul 23;13:752. doi: 10.3389/fnins.2019.00752. eCollection 2019.
5
Neuron-Glia Signaling in Synapse Elimination.神经元-胶质细胞信号在突触消除中的作用。
Annu Rev Neurosci. 2019 Jul 8;42:107-127. doi: 10.1146/annurev-neuro-070918-050306.
6
TREM2 is required for microglial instruction of astrocytic synaptic engulfment in neurodevelopment.TREM2 在神经发育过程中，小胶质细胞对星形胶质细胞突触吞噬的指令作用是必需的。
Glia. 2019 Oct;67(10):1873-1892. doi: 10.1002/glia.23664. Epub 2019 Jul 2.
7
Extract Ameliorates Scopolamine-Induced Cognitive Impairment in Mice.提取物可改善东莨菪碱致小鼠认知障碍。
J Med Food. 2019 Jul;22(7):685-695. doi: 10.1089/jmf.2018.4302. Epub 2019 Jun 21.
8
The p75 Neurotrophin Receptor Is an Essential Mediator of Impairments in Hippocampal-Dependent Associative Plasticity and Memory Induced by Sleep Deprivation.p75 神经营养因子受体是睡眠剥夺诱导的海马依赖性联想性可塑性和记忆损伤的必需介质。
J Neurosci. 2019 Jul 10;39(28):5452-5465. doi: 10.1523/JNEUROSCI.2876-18.2019. Epub 2019 May 13.
9
Microglial phagocytosis in aging and Alzheimer's disease.衰老与阿尔茨海默病中的小胶质细胞吞噬作用。
J Neurosci Res. 2020 Feb;98(2):284-298. doi: 10.1002/jnr.24419. Epub 2019 Apr 3.
10
A neuronal molecular switch through cell-cell contact that regulates quiescent neural stem cells.通过细胞间接触调节静息神经干细胞的神经元分子开关。
Sci Adv. 2019 Feb 27;5(2):eaav4416. doi: 10.1126/sciadv.aav4416. eCollection 2019 Feb.