Gaur Archana, Pal G K, Pal Pravati
Department of Physiology, All India Institute of Medical Sciences (AIIMS)Jodhpur, Jodhpur, Rajasthan, India.
Department of Physiology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, Pondicherry, India.
Ann Neurosci. 2021 Jan;28(1-2):39-46. doi: 10.1177/09727531211005738. Epub 2021 May 21.
Obesity is because of excessive fat accumulation that affects health adversely in the form of various diseases such as diabetes, hypertension, cardiovascular diseases, and many other disorders. Our Indian diet is rich in carbohydrates, and hence the sucrose-induced obesity is an apt model to mimic this. Ventromedial hypothalamus (VMH) is linked to the regulation of food intake in animals as well as humans.
To understand the role of VMHin sucrose-induced obesity on metabolic parameters.
A total of 24 adult rats were made obese by feeding them on a 32% sucrose solution for 10 weeks. The VMH nucleus was ablated in the experimental group and sham lesions were made in the control group. Food intake, body weight, and biochemical parameters were compared before and after the lesion.
Male rats had a significant weight gain along with hyperphagia, whereas female rats did not have a significant weight gain inspite of hyperphagia. Insulin resistance and dyslipidemia were seen in both the experimental and control groups.
A sucrose diet produces obesity which is similar to the metabolic syndrome with insulin resistance and dyslipidemia, and a VMH lesion further exaggerates it. Males are more prone to this exaggeration.
肥胖是由于脂肪过度堆积，会以糖尿病、高血压、心血管疾病及许多其他病症等多种疾病的形式对健康产生不利影响。我们的印度饮食富含碳水化合物，因此蔗糖诱导的肥胖是模拟这种情况的合适模型。腹内侧下丘脑（VMH）与动物及人类的食物摄入调节有关。
了解VMH在蔗糖诱导的肥胖中对代谢参数的作用。
通过给24只成年大鼠喂食32%的蔗糖溶液10周使其肥胖。对实验组的VMH核进行损毁，对照组进行假损毁。比较损毁前后的食物摄入量、体重和生化参数。
雄性大鼠体重显著增加并伴有摄食过多，而雌性大鼠尽管摄食过多但体重没有显著增加。实验组和对照组均出现胰岛素抵抗和血脂异常。
蔗糖饮食会导致肥胖，类似于伴有胰岛素抵抗和血脂异常的代谢综合征，VMH损伤会使其进一步加剧。雄性更容易出现这种加剧情况。
