van Aalst June, Jennen Lise, Demyttenaere Koen, Sunaert Stefan, Koole Michel, Ceccarini Jenny, Van Laere Koen
Nuclear Medicine and Molecular Imaging, Department of Imaging and Pathology, KU Leuven, Leuven, Belgium.
Research Group Psychiatry, Neurosciences, University Psychiatric Center KU Leuven, Leuven, Belgium.
Front Psychiatry. 2021 Oct 18;12:739356. doi: 10.3389/fpsyt.2021.739356. eCollection 2021.
Interventional yoga studies with an active control group remain scarce and are important to clarify the underlying neurobiology. We conducted an interventional study in healthy controls using simultaneous positron emission tomography/magnetic resonance (PET/MR) imaging and psychometric scales. Thirty healthy, female volunteers (28.4 ± 8.4 years) participated and were randomly assigned to a 12-week yoga or indoor cycling intervention. Before and after the intervention, [F]FDG and [C]UCB-J PET was performed on a simultaneous GE Signa PET/MR with volumetric imaging. Psychometric scales were evaluated on affect, mindfulness, stress, worrying, self-compassion, and interoceptive awareness. Yoga subjects scored higher on interoceptive awareness compared to baseline ( < 0.001). Cognitive ( = 0.009) and overall cognitive functioning ( = 0.01) improved after the yoga intervention compared to the cycling group. We did not observe significant differences in glucose metabolism, synaptic density, or gray matter (GM) volume. The indoor cycling group did not show changes in psychometric variables, but significant increases in relative glucose metabolism were observed in the parahippocampal/fusiform gyrus and cerebellum ( < 0.001). In conclusion, 12 weeks of yoga practice has significant effects on interoceptive awareness and perceived cognitive function in starters. Longer interventions and/or higher frequency of yoga practice may be needed to detect cerebral metabolic and/or morphologic effects on the macroscopic level.
采用活性对照组的介入性瑜伽研究仍然较少，而这类研究对于阐明潜在的神经生物学机制很重要。我们对健康对照组进行了一项介入性研究，采用正电子发射断层扫描/磁共振成像（PET/MR）同步成像和心理测量量表。30名健康女性志愿者（28.4±8.4岁）参与研究，并被随机分配到为期12周的瑜伽或室内自行车运动干预组。在干预前后，使用GE Signa PET/MR同步进行[F]FDG和[C]UCB-J PET的容积成像。对情感、正念、压力、担忧、自我同情和内感受性觉知等心理测量量表进行评估。与基线相比，瑜伽组在内感受性觉知方面得分更高（<0.001）。与骑行组相比，瑜伽干预后认知（=0.009）和整体认知功能（=0.01）有所改善。我们未观察到葡萄糖代谢、突触密度或灰质（GM）体积有显著差异。室内自行车运动组在心理测量变量方面未显示出变化，但在海马旁回/梭状回和小脑观察到相对葡萄糖代谢显著增加（<0.001）。总之，12周的瑜伽练习对初学者的内感受性觉知和感知认知功能有显著影响。可能需要更长时间的干预和/或更高频率的瑜伽练习，才能在宏观层面检测到对脑代谢和/或形态学的影响。
