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骨质疏松症药物治疗最新进展

Osteoporosis Drug Treatment Update.

作者信息

Oliveira Lindomar Guimarães, Carneiro Mara Lúcia Rassi Guimarães, Souza Márcio Passini Gonçalves de, Souza Caio Gonçalves de, Moraes Frederico Barra de, Camargo Fábio Lopes de

机构信息

Departamento de Ortopedia e Traumatologia, Universidade Federal de Goiás, Goiânia, GO, Brasil.

Instituto de Ortopedia e Traumatologia, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brasil.

出版信息

Rev Bras Ortop (Sao Paulo). 2021 Oct 28;56(5):550-557. doi: 10.1055/s-0040-1714219. eCollection 2021 Oct.

Abstract

The Brazilian population is aging and the prevalence of chronic degenerative diseases, including osteoporosis, is increasing. The diagnosis and treatment of osteoporosis have made significant advances in the last decade. The orthopedist and traumatologist can no longer be detained only in the surgical treatment of osteoporotic fracture. It is extremely important that we know: 1) what risk factors to evaluate, and the Fracture Risk Assesment Tool (FRAX) can be used; 2) which complementary tests should be requested, such as densitometry, radiography of the spine and pelvis, blood and urine tests, and even bone biopsy; 3) which supplements to use, such as calcium and magnesium, vitamins D and K; 4) which medications to prescribe, antiresorptives or trainers, therapeutic windows and adverse events.

摘要

巴西人口正在老龄化,包括骨质疏松症在内的慢性退行性疾病的患病率正在上升。在过去十年中,骨质疏松症的诊断和治疗取得了重大进展。骨科医生和创伤科医生不能再仅仅局限于骨质疏松性骨折的手术治疗。我们必须清楚地了解:1)评估哪些风险因素,可使用骨折风险评估工具(FRAX);2)应要求进行哪些补充检查,如骨密度测定、脊柱和骨盆X线检查、血液和尿液检查,甚至骨活检;3)使用哪些补充剂,如钙和镁、维生素D和K;4)开哪些药物,抗吸收剂还是促骨形成剂,治疗窗口和不良事件。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50e3/8558937/11e8ecaef4eb/10-1055-s-0040-1714219-i2000025en-1.jpg

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