Raikundalia Milap D, Huang Ryan J, Chan Lyndon, Truong Tracy, Kuchibhatla Maragatha, Merchant James, Hachem Ralph Abi, Codd Patrick J, Zomorodi Ali R, Teitelbaum Jordan I, Goldstein Bradley J, Jang David W
Department of Head and Neck Surgery & Communication Sciences, Duke University, Durham, USA.
Duke University School of Medicine, Durham, USA.
Allergy Rhinol (Providence). 2021 Oct 29;12:21526567211045041. doi: 10.1177/21526567211045041. eCollection 2021 Jan-Dec.
To assess olfactory outcomes as measured by an olfactory-specific quality of life (QOL) questionnaire in patients undergoing EESBS for sellar lesions.
Retrospective case series.
Tertiary academic medical center.
In total, 36 patients undergoing EESBS for lesions limited to the sella were evaluated.
The following were performed before and three months after surgery: 22-Item Sinonasal Outcomes Test (SNOT-22), University of Pennsylvania Smell Identification Test (UPSIT), and the Assessment of Self-reported Olfactory Functioning (ASOF), which has three domains: subjective olfactory capability scale (SOC), smell-related problems (SRP), and olfactory-related quality of life (ORQ).
Median age at surgery was 52.5 years, with a median tumor size of 1.8 cm (range: 0.2 to 3.9 cm). Pre- and postoperative median scores were 35 [34, 36.2] and 34.5 [32, 36] for UPSIT, 21 [7.5, 33.5] and 21.5 [6.8, 35.7] for SNOT-22, 10 [9, 10] and 9 [8, 10] for ASOF-SOC, 5 [4.8, 5] and 4.5 [4, 5] for ASOF-SRP, and 5 [5, 5] and 5 [4.5, 5] for ASOF-ORQ. There was no significant change in the two of the three domains of the ASOF. Correlation between ASOF and UPSIT scores were weak. Older age and larger tumor size were associated with worsened olfaction after surgery.
Patients did not experience significant changes in olfactory-specific QOL three months after EESBS, as measured by two domains of the ASOF. The ASOF may serve as a useful adjunctive tool for assessing olfaction after surgery. The lack of correlation between UPSIT and ASOF suggests the need for more research in subjective olfactory-related quality of life after surgery.
通过嗅觉特异性生活质量（QOL）问卷评估经鼻蝶扩大入路手术（EESBS）治疗鞍区病变患者的嗅觉结果。
回顾性病例系列研究。
三级学术医学中心。
总共评估了36例因局限于鞍区的病变而接受EESBS的患者。
在手术前和术后三个月进行以下检查：22项鼻鼻窦结局测试（SNOT-22）、宾夕法尼亚大学嗅觉识别测试（UPSIT）以及自我报告嗅觉功能评估（ASOF），ASOF有三个领域：主观嗅觉能力量表（SOC）、嗅觉相关问题（SRP）和嗅觉相关生活质量（ORQ）。
手术时的中位年龄为52.5岁，肿瘤中位大小为1.8 cm（范围：0.2至3.9 cm）。UPSIT术前和术后的中位分数分别为35 [34, 36.2]和34.5 [32, 36]，SNOT-22分别为21 [7.5, 33.5]和21.5 [6.8, 35.7]，ASOF-SOC分别为10 [9, 10]和9 [8, 10]，ASOF-SRP分别为5 [4.8, 5]和4.5 [4, 5]，ASOF-ORQ分别为5 [5, 5]和5 [4.5, 5]。ASOF的三个领域中的两个没有显著变化。ASOF与UPSIT分数之间的相关性较弱。年龄较大和肿瘤较大与术后嗅觉恶化有关。
根据ASOF的两个领域衡量，患者在EESBS术后三个月嗅觉特异性QOL没有显著变化。ASOF可作为评估术后嗅觉的有用辅助工具。UPSIT与ASOF之间缺乏相关性表明需要对术后主观嗅觉相关生活质量进行更多研究。
