Department of Biology, School of Basic Sciences, Science and Research Branch, Islamic Azad University (IAU), Tehran, Iran.
Department of Medical Genetics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Mol Biol Rep. 2022 Feb;49(2):1429-1436. doi: 10.1007/s11033-021-06892-y. Epub 2021 Nov 3.
Diabetes mellitus (DM) is a chronic metabolic disorder, increasing in the number of patients and poses a severe threat to human health. Significant advances have been made in DM treatment; the most important of which is differentiation and proliferation of beta cells from IPSCs.
Data were collected from PUBMED at various time points up to the academic year of 2020. The related keywords are listed as follows: "Induced pluripotent stem cell", "Proliferation", "Growth factor", "Small molecule", "cardiotoxicity" and "Scaffold."
The use of growth factors along with small molecules can be a good strategy for beta-cell proliferation. Also, proliferation of beta cells on nanofibers scaffolds can create a similar in vivo environment, that leads to increased function of beta-cell. Some transcription factors that cause beta cells proliferation play an important role in inflammation; so, it is essential to monitor them to prevent inflammation.
Finally, the simultaneous use of growth factors, micronutrients and scaffolds can be an excellent strategy to increase the proliferation and function of beta cells derived from IPSCs.
糖尿病（DM）是一种慢性代谢紊乱疾病，患者数量不断增加，严重威胁人类健康。DM 的治疗取得了重大进展，其中最重要的是从 IPSC 中分化和增殖β细胞。
数据截至 2020 学年，通过 PUBMED 在不同时间点收集。相关关键词如下：“诱导多能干细胞”、“增殖”、“生长因子”、“小分子”、“心脏毒性”和“支架”。
使用生长因子和小分子可以是β细胞增殖的良好策略。此外，在纳米纤维支架上增殖β细胞可以创建类似的体内环境，从而提高β细胞的功能。一些导致β细胞增殖的转录因子在炎症中发挥重要作用；因此，必须对其进行监测以预防炎症。
最后，生长因子、微量营养素和支架的同时使用可能是提高 IPSC 来源的β细胞增殖和功能的绝佳策略。
