Marholin D, Pohl R E, Stewart R M, Touchette P E, Townsend N M, Kolodny E H
Pediatr Res. 1978 Mar;12(3):179-87. doi: 10.1203/00006450-197803000-00004.
The effects of a low phenylalanine diet on six retarded phenylketonuric adults were assessed. An ABA individual-subject design was used in experiment I to assess the effects of a low phenylalanine diet on social and motor behavior. Following a baseline during which the subjects ingested a normal phenylalanine diet (phase A), a low phenylalanine diet (phase B) was administered in a double blind fashion. Finally, the baseline condition (phase A) was reinstated (normal diet). The low phenylalanine diet resulted in few significant behavioral changes for those subjects with which proper methodologic controls were employed. However, for two of six subjects motor behavior, including stereotypy and tremor, seem to have ameliorated. In experiment II, applied behavior analysis techniques, including differential reinforcement of other behavior and time out, were combined to radically reduce the frequency of stereotypy and self-abuse exhibited by one of the six subjects of experiment I.
评估了低苯丙氨酸饮食对六名智力发育迟缓的苯丙酮尿症成年人的影响。在实验一中采用ABA个体受试者设计，以评估低苯丙氨酸饮食对社交和运动行为的影响。在受试者摄入正常苯丙氨酸饮食的基线期（A阶段）之后，以双盲方式给予低苯丙氨酸饮食（B阶段）。最后，恢复基线条件（A阶段，正常饮食）。对于采用了适当方法学控制的受试者，低苯丙氨酸饮食导致的行为变化不显著。然而，六名受试者中有两名的运动行为，包括刻板动作和震颤，似乎有所改善。在实验二中，应用行为分析技术，包括对其他行为的差别强化和暂停，相结合以从根本上减少实验一中六名受试者之一所表现出的刻板动作和自我伤害行为的频率。
